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Scientific article
English

Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study

Published inThe Lancet Neurology, vol. 18, no. 12, p. 1103-1111
Publication date2019
Abstract

Neurofilament light chain (NfL) is a promising blood biomarker in genetic frontotemporal dementia, with elevated concentrations in symptomatic carriers of mutations in GRN, C9orf72, and MAPT. A better understanding of NfL dynamics is essential for upcoming therapeutic trials. We aimed to study longitudinal NfL trajectories in people with presymptomatic and symptomatic genetic frontotemporal dementia.

Keywords
  • Adult
  • Aged
  • Biomarkers/blood
  • C9orf72 Protein/genetics
  • Cohort Studies
  • Female
  • Frontotemporal Dementia/blood/diagnostic imaging/genetics
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neurofilament Proteins/blood/genetics
Citation (ISO format)
VAN DER ENDE, Emma L et al. Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study. In: The Lancet Neurology, 2019, vol. 18, n° 12, p. 1103–1111. doi: 10.1016/S1474-4422(19)30354-0
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Identifiers
ISSN of the journal1474-4422
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Technical informations

Creation07/10/2020 11:51:00 AM
First validation07/10/2020 11:51:00 AM
Update time03/15/2023 10:18:56 PM
Status update03/15/2023 10:18:52 PM
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