Background: Continuity of care between hospitals and community pharmacies needs to be improved to ensure medication safety. This study aimed to evaluate whether a set of pharmaceutical interventions to prepare hospital discharge facilitates the transition of care. Methods: This study took place in the internal medicine ward and in surrounding community pharmacies. The intervention group's patients underwent a set of pharmaceutical interventions during their hospital stay: medication reconciliation at admission, medication review, and discharge planning. The two groups were compared with regards to: number of community pharmacist interventions, time spent on discharge prescriptions, and number of treatment changes. Results: Comparison between the groups showed a much lower (77% lower) number of community pharmacist interventions per discharge prescription in the intervention (n = 54 patients) compared to the control group (n = 64 patients): 6.9 versus 1.6 interventions, respectively (p < 0.0001); less time working on discharge prescriptions; less interventions requiring a telephone call to a hospital physician. The number of medication changes at different steps was also significantly lower in the intervention group: 40% fewer (p < 0.0001) changes between hospital admission and discharge, 66% fewer (p < 0.0001) between hospital discharge and community pharmacy care, and 25% fewer ( p= 0.002) between community pharmacy care and care by a general practitioner. Conclusion: An intervention group underwent significantly fewermedication changes in subsequent steps in the transition of care after a set of interventions performed during their hospital stay. Community pharmacists had to perform fewer interventions on discharge prescriptions. Altogether, this improves continuity of care. (C)2016 European Federation of Internal Medicine. Published by Elsevier B. V. All rights reserved.