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Title

Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases

Authors
Aaronson, Jeffrey
Yohe, Stefan
Kelley, Robert F
Published in Expert opinion on drug delivery. 2019, vol. 16, no. 1, p. 43-57
Abstract Treating posterior eye diseases has become a major area of focus for pharmaceutical and biotechnology companies. Current standard of care for treating posterior eye diseases relies on administration via intravitreal injection. Although effective, this is not without complications and there is great incentive to develop longer-acting therapeutics and/or sustained release delivery systems. Here, we present an overview of emerging technologies for delivery of biologics to the back of the eye.
Keywords AnimalsBiological AvailabilityDrug Delivery SystemsEye/metabolismEye Diseases/drug therapyHumansIntravitreal InjectionsMacular Degeneration/drug therapy
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PMID: 30488721
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SHATZ, Whitney Lauren et al. Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases. In: Expert Opinion on Drug Delivery, 2019, vol. 16, n° 1, p. 43-57. doi: 10.1080/17425247.2019.1553953 https://archive-ouverte.unige.ch/unige:138474

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Deposited on : 2020-07-17

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