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Title

Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters

Authors
Daneluti, André Luis Máximo
Neto, Francisco Mariano
Ruscinc, Nádia
Lopes, Ingrid
Robles Velasco, Maria Valéria
Do Rosário Matos, Jivaldo
Baby, André Rolim
Published in International journal of pharmaceutics. 2019, vol. 570, 118633
Abstract Avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC), are widely used UV filters. The aim of this study was to investigate the effect of incorporation in mesoporous silica (SBA-15) on their cutaneous deposition and permeation. Stick formulations containing "free" and "incorporated" UV filters (SF1 and SF2, respectively) were prepared and characterized with respect to their physicochemical, thermal, and functional properties. Cutaneous delivery experiments using porcine skin with quantification by UHPLC-MS/MS, demonstrated that skin deposition of AVO and OXY after application of SF2 for 6 and 12 h was significantly lower than that from SF1 at each time-point (Student t-test, p < 0.05): e.g. OXY permeation across the skin was 30-, 12- and 1.5-fold lower after 6, 12 and 24 h, respectively, following application of SF2. Cutaneous biodistribution profiles of AVO and OXY to 800 µm evidenced a significant decrease in the amounts in the viable epidermis and dermis. In contrast, deposition of the more lipophilic OMC was not significantly different (p ˃ 0.05). In vitro photoprotective efficacy results demonstrated that adsorption/entrapment of UV filters enhanced the sun protection factor by 94%. In conclusion, SBA-15, an innovative mesoporous material, increased photoprotection by UV filters while reducing their cutaneous penetration and transdermal permeation.
Keywords Administration, CutaneousAnimalsBenzophenones/chemistryChromatography, High Pressure Liquid/methodsCinnamates/chemistryDermis/metabolismDrug Carriers/chemistryDrug Compounding/methodsDrug StabilityEpidermis/metabolismPropiophenones/chemistrySilicon Dioxide/blood/chemistrySkin Absorption/drug effectsSun Protection Factor/methodsSunscreening Agents/administration & dosage/chemistrySwineTandem Mass Spectrometry/methodsTissue Distribution/physiologyUltraviolet Rays/adverse effects
Identifiers
PMID: 31437563
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DANELUTI, André Luis Máximo et al. Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters. In: International Journal of Pharmaceutics, 2019, vol. 570, p. 118633. doi: 10.1016/j.ijpharm.2019.118633 https://archive-ouverte.unige.ch/unige:138465

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Deposited on : 2020-07-17

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