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Scientific article
English

Prevention of age-induced N(ε)-(carboxymethyl)lysine accumulation in the microvasculature

Published inEuropean Journal of Clinical Investigation, vol. 46, no. 4, p. 334-341
Publication date2016
Abstract

N(ε)-(carboxymethyl)lysine (CML) is one of the major advanced glycation end products in both diabetics and nondiabetics. CML depositions in the microvasculature have recently been linked to the aetiology of acute myocardial infarction and cognitive impairment in Alzheimer's disease, possibly related to local enhancement of inflammation and oxidative processes. We hypothesized that CML deposition in the microvasculature of the heart and brain is age-induced and that it could be inhibited by a diet intervention with docosahexaenoic acid (DHA), an omega-3 fatty acid known for its anti-inflammatory and antioxidative actions.

Keywords
  • Aging/metabolism
  • Animals
  • Apolipoproteins E/deficiency
  • Brain/blood supply
  • Coronary Vessels/metabolism
  • Endothelium, Vascular/metabolism
  • Lysine/analogs & derivatives/metabolism
  • Mice, Inbred Strains
  • Microvessels/metabolism
  • Superoxide Dismutase/metabolism
  • Survival Rate
Affiliation Not a UNIGE publication
Citation (ISO format)
FUIJKSCHOT, Wessel W et al. Prevention of age-induced N(ε)-(carboxymethyl)lysine accumulation in the microvasculature. In: European Journal of Clinical Investigation, 2016, vol. 46, n° 4, p. 334–341. doi: 10.1111/eci.12599
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0014-2972
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