Auditory deviance detection in the human insula: An intracranial EEG study

Blenkmann, Alejandro O; Collavini, Santiago; Lubell, James; Llorens, Anaïs; Funderud, Ingrid; Ivanovic, Jugoslav; Larsson, Pål G; Meling, Torstein; Bekinschtein, Tristan; Kochen, Silvia; Endestad, Tor; Knight, Robert T; Solbakk, Anne-Kristin

doi:10.1016/j.cortex.2019.09.002

Scientific article

English

Auditory deviance detection in the human insula: An intracranial EEG study

Contributors

Blenkmann, Alejandro O; Collavini, Santiago; Lubell, James; Llorens, Anaïs; Funderud, Ingrid; Ivanovic, Jugoslav; Larsson, Pål G; Meling, Torstein; Bekinschtein, Tristan; Kochen, Silvia; Endestad, Tor; Knight, Robert T; Solbakk, Anne-Kristin

Published in

Cortex, vol. 121, p. 189-200

Publication date

2019

Abstract

The human insula is known to be involved in auditory processing, but knowledge about its precise functional role and the underlying electrophysiology is limited. To assess its role in automatic auditory deviance detection we analyzed the EEG high frequency activity (HFA; 75-145 Hz) and ERPs from 90 intracranial insular channels across 16 patients undergoing pre-surgical intracranial monitoring for epilepsy treatment. Subjects passively listened to a stream of standard and deviant tones differing in four physical dimensions: intensity, frequency, location or time. HFA responses to auditory stimuli were found in the short and long gyri, and the anterior, superior, and inferior segments of the circular sulcus of the insular cortex. Only a subset of channels in the inferior segment of the circular sulcus of the insula showed HFA deviance detection responses, i.e., a greater and longer latency response to specific deviants relative to standards. Auditory deviancy processing was also later in the insula when compared with the superior temporal cortex. ERP results were more widespread and supported the HFA insular findings. These results provide evidence that the human insula is engaged during auditory deviance detection.

Keywords

Insula
Deviance detection
Mismatch negativity (MMN)
High frequency activity
Predictive coding

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Citation (ISO format)

BLENKMANN, Alejandro O et al. Auditory deviance detection in the human insula: An intracranial EEG study. In: Cortex, 2019, vol. 121, p. 189–200. doi: 10.1016/j.cortex.2019.09.002

Article (Accepted version)

Identifiers

PID : unige:138352
DOI : 10.1016/j.cortex.2019.09.002
PMID : 31629197

Additional URL for this publication

https://www.sciencedirect.com/science/article/pii/S0010945219303119

Datasets

https://osf.io/4u36q/

Journal ISSN

0010-9452

302views

620downloads

Creation

27/05/2020 15:21:00

First validation

27/05/2020 15:21:00

Update

15/03/2023 22:15:57

Status update

15/03/2023 22:15:57

Last indexation

31/10/2024 19:10:42

Auditory deviance detection in the human insula: An intracranial EEG study

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Datasets

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation