Medicinal Plants to Treat Epilepsy: Discovery of Antiseizure Compounds by In Vivo Zebrafish Bioactivity-Guided Isolation

Brillatz, Théo

doi:10.13097/archive-ouverte/unige:138129

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Title		Medicinal Plants to Treat Epilepsy: Discovery of Antiseizure Compounds by In Vivo Zebrafish Bioactivity-Guided Isolation
Author		Brillatz, Théo
Director		Wolfender, Jean-Luc
Defense		Thèse de doctorat : Univ. Genève, 2020 - Sc. 5452 - 2020/04/03
Abstract		Epilepsy is a chronic neurological disorder characterized by recurrent epileptic seizures which affects 1% of the world’s population, of whom 80% live in low- and middle-income countries. Antiseizure drugs (ASDs) and therapies are available for epilepsy management but despite these possibilities, a third of epileptic patients suffer from pharmaco-resistance. There is, therefore, an urgent need for new and cost-effective treatments to manage epilepsy. Herbs used in traditional medicine remain the first-line treatment for most people with limited access to ASDs. Thus, in this thesis, three plants traditionally used to treat epilepsy and CNS-related disorders were selected and studied using a bioactivity-guided isolation protocol combined to an in vivo zebrafish epilepsy model to effectively identify compounds with significant antiseizure activity. This work demonstrated the chemical diversity of antiseizure constituents and their mode of action which may help to provide evidence-based data for the management of epilepsy with well-selected medicinal herbs.
Keywords		Epilepsy — Traditional medicine — Zebrafish — Bioactivity-guided isolation — Cyperus articulatus — Helleborus odorus subsp. cyclophyllus — Boswellia sacra — Zingiber purpureum — Skeletonema marinoi
Identifiers		DOI: 10.13097/archive-ouverte/unige:138129 URN: urn:nbn:ch:unige-1381295
Full text		Thesis (34.2 MB) - Private access (until 2024-06-25)
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Research group		Phytochimie et produits naturels bioactifs
Citation (ISO format)		BRILLATZ, Théo. Medicinal Plants to Treat Epilepsy: Discovery of Antiseizure Compounds by In Vivo Zebrafish Bioactivity-Guided Isolation. Université de Genève. Thèse, 2020. doi: 10.13097/archive-ouverte/unige:138129 https://archive-ouverte.unige.ch/unige:138129