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Title

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

Authors
Zeeshan, Mohammad
Rea, Edward
Mourier, Tobias
Subudhi, Amit Kumar
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Published in eLife. 2020, vol. 9, p. e56474
Abstract Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. We show that Plasmodium berghei CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is required for mosquito transmission. It phosphorylates canonical CDK motifs of components in the pre-replicative complex and is essential for DNA replication. During a replicative cycle, CRK5 stably interacts with a single Plasmodium-specific cyclin (SOC2), although we obtained no evidence of SOC2 cycling by transcription, translation or degradation. Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication.
Keywords Cyclincell cyclekinasePlasmodiumtransmission
Identifiers
PMID: 32568069
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Structures
Research group Signalisation chez les parasites du paludisme (955)
Projects FNS: BSSGI0_155852
FNS: 31003A_179321
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(ISO format)
BALESTRA, Aurélia et al. A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission. In: eLife, 2020, vol. 9, p. e56474. doi: 10.7554/eLife.56474 https://archive-ouverte.unige.ch/unige:137985

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Deposited on : 2020-06-26

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