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Title

Tests préimplantatoires de l’embryon en médecine de reproduction

Authors
Murisier, Fabien
Published in Revue médicale suisse. 2019, vol. 15, no. 632-633, p. 53-56
Abstract Preimplantation genetic testing avoids the transmission of monogenic diseases or structural chromosome abnormality to the offspring in fertile couples. Furthermore, it allows screening for aneuploidies (PGT-A, Preimplantation genetic testing for aneuploidy), with the aim of selecting one euploid embryo before transfer in infertile couples undergoing in vitro fertilization (IVF). Indeed, aneuploidies are frequent and explain most IVF failures and early miscarriages. The indications for PGT-A remain controversial, due to the lack of clear evidence of improved outcomes after IVF. Cost-effectiveness studies and follow-up of neonatal outcomes are needed. Finally, each situation requires counseling taking into account ethical considerations.
Keywords AneuploidyFemaleFertilization in VitroGenetic TestingHumansInfertilityPregnancyPreimplantation Diagnosis
Identifiers
PMID: 30629370
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Article (Published version) (564 Kb) - public document Free access
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Research group Groupe Giacobino Ariane (génétique) (923)
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BENARD, Julie Gabrielle Anne et al. Tests préimplantatoires de l’embryon en médecine de reproduction. In: Revue médicale suisse, 2019, vol. 15, n° 632-633, p. 53-56. https://archive-ouverte.unige.ch/unige:137980

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Deposited on : 2020-06-26

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