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Title

Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE)

Authors
Schmitz, Thomas
Alberti, Corinne
Ursino, Moreno
Aupiais, Camille
Collaboration
Published in BMC Pregnancy and Childbirth. 2019, vol. 19, no. 1, p. 67
Abstract Although antenatal betamethasone is recommended worldwide for women at risk of preterm delivery, concerns persist regarding the long-term effects associated with this treatment. Indeed, adverse events, mainly dose-related, have been reported. The current recommended dose of antenatal betamethasone directly derives from sheep experiments performed in the late 60's and has not been challenged in 45 years. Therefore, randomized trials evaluating novel dose regimens are urgently needed.
Keywords Betamethasone/administration & dosageClinical ProtocolsDouble-Blind MethodFemaleFranceGlucocorticoids/administration & dosageHumansInfant, NewbornPregnancyPremature Birth/drug therapyPrenatal Care/methodsRandomized Controlled Trials as TopicResearch DesignRespiratory Distress Syndrome, Newborn/drug therapy/prevention & control
Identifiers
PMID: 30755164
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Structures
Research group Prévention des complications néonatales d'origine périnatale (990)
Citation
(ISO format)
SCHMITZ, Thomas et al. Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE). In: BMC Pregnancy and Childbirth, 2019, vol. 19, n° 1, p. 67. doi: 10.1186/s12884-019-2206-x https://archive-ouverte.unige.ch/unige:137381

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Deposited on : 2020-06-18

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