Scientific article
OA Policy
English

Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE)

Published in

BMC Pregnancy and Childbirth, vol. 19, no. 1, 67

Publication date

2019

Abstract

Although antenatal betamethasone is recommended worldwide for women at risk of preterm delivery, concerns persist regarding the long-term effects associated with this treatment. Indeed, adverse events, mainly dose-related, have been reported. The current recommended dose of antenatal betamethasone directly derives from sheep experiments performed in the late 60's and has not been challenged in 45 years. Therefore, randomized trials evaluating novel dose regimens are urgently needed.

Keywords

  • Betamethasone/administration & dosage
  • Clinical Protocols
  • Double-Blind Method
  • Female
  • France
  • Glucocorticoids/administration & dosage
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Premature Birth/drug therapy
  • Prenatal Care/methods
  • Randomized Controlled Trials as Topic
  • Research Design
  • Respiratory Distress Syndrome, Newborn/drug therapy/prevention & control

Citation (ISO format)

SCHMITZ, Thomas et al. Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE). In: BMC Pregnancy and Childbirth, 2019, vol. 19, n° 1, p. 67. doi: 10.1186/s12884-019-2206-x

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1471-2393
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230downloads

Technical informations

Creation

18/06/2020 11:06:00

First validation

18/06/2020 11:06:00

Update

13/10/2025 17:18:10

Status update

15/03/2023 22:09:42

Last indexation

10/11/2026 17:37:45
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