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Mitochondrial ion channels as targets for cardioprotection

Published inJournal of Cellular and Molecular Medicine, vol. 24, no. 13, p. 7102-7114
Publication date2020
Abstract

Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. In this article, we review the role of mitochondrial ion channels, which are known to modulate susceptibility to acute myocardial I/R injury, and we explore their potential roles as therapeutic targets for reducing MI size and preventing HF following AMI.

Citation (ISO format)
HAUSENLOY, Derek J et al. Mitochondrial ion channels as targets for cardioprotection. In: Journal of Cellular and Molecular Medicine, 2020, vol. 24, n° 13, p. 7102–7114. doi: 10.1111/jcmm.15341
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ISSN of the journal1582-1838
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Creation06/09/2020 6:48:00 PM
First validation06/09/2020 6:48:00 PM
Update time03/15/2023 10:08:09 PM
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