UNIGE document Scientific Article - Review
previous document  unige:137282  next document
add to browser collection
Title

Mitochondrial ion channels as targets for cardioprotection

Authors
Hausenloy, Derek J
Schulz, Rainer
Girao, Henrique
De Stefani, Diego
Rizzuto, Rosario
Bernardi, Paolo
Di Lisa, Fabio
Published in Journal of Cellular and Molecular Medicine. 2020, vol. 24, no. 13, p. 7102-14
Abstract Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. In this article, we review the role of mitochondrial ion channels, which are known to modulate susceptibility to acute myocardial I/R injury, and we explore their potential roles as therapeutic targets for reducing MI size and preventing HF following AMI.
Identifiers
PMID: 32490600
Full text
Article (Published version) (677 Kb) - public document Free access
Structures
Research group L'athérosclérose (665)
Projects FNS: 310030E_176050
FNS: IZCOZ0_189878
Citation
(ISO format)
HAUSENLOY, Derek J et al. Mitochondrial ion channels as targets for cardioprotection. In: Journal of Cellular and Molecular Medicine, 2020, vol. 24, n° 13, p. 7102-14. doi: 10.1111/jcmm.15341 https://archive-ouverte.unige.ch/unige:137282

84 hits

37 downloads

Update

Deposited on : 2020-06-17

Export document
Format :
Citation style :