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Mitochondrial ion channels as targets for cardioprotection

Hausenloy, Derek J
Schulz, Rainer
Girao, Henrique
De Stefani, Diego
Rizzuto, Rosario
Bernardi, Paolo
Di Lisa, Fabio
Published in Journal of Cellular and Molecular Medicine. 2020, vol. 24, no. 13, p. 7102-14
Abstract Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. In this article, we review the role of mitochondrial ion channels, which are known to modulate susceptibility to acute myocardial I/R injury, and we explore their potential roles as therapeutic targets for reducing MI size and preventing HF following AMI.
PMID: 32490600
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Article (Published version) (677 Kb) - public document Free access
Research group L'athérosclérose (665)
Projects FNS: 310030E_176050
FNS: IZCOZ0_189878
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HAUSENLOY, Derek J et al. Mitochondrial ion channels as targets for cardioprotection. In: Journal of Cellular and Molecular Medicine, 2020, vol. 24, n° 13, p. 7102-14. doi: 10.1111/jcmm.15341 https://archive-ouverte.unige.ch/unige:137282

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Deposited on : 2020-06-17

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