Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension

Ferrari, Serge Livio; Eastell, Richard; Napoli, Nicola; Schwartz, Ann; Hofbauer, Lorenz C.; Chines, Arkadi; Wang, Andrea; Pannacciulli, Nico; Cummings, Steven R.

doi:10.1016/j.bone.2020.115268

Scientific article

English

Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension

ContributorsFerrari, Serge Livio; Eastell, Richard; Napoli, Nicola; Schwartz, Ann; Hofbauer, Lorenz C.; Chines, Arkadi; Wang, Andrea; Pannacciulli, Nico; Cummings, Steven R.

Published inBone, vol. 134, 115268

Publication date2020

Abstract

Diabetes and osteoporosis occur frequently in older adults and are both associated with increased fracture risk. Denosumab treatment reduced new vertebral, nonvertebral, and hip fractures over 3 years, with continued low fracture incidence for up to 10 years in postmenopausal women with osteoporosis. However, its effects in diabetic subjects with osteoporosis have not yet been investigated.

Keywords

Diseases and disorders of/related to bone
Osteoporosis
Clinical trials
Therapeutics antiresorptive

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Funding

European Commission - Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach [860898]

Citation (ISO format)

FERRARI, Serge Livio et al. Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension. In: Bone, 2020, vol. 134, p. 115268. doi: 10.1016/j.bone.2020.115268

Article (Published version)

Identifiers

PID : unige:137068
DOI : 10.1016/j.bone.2020.115268
PMID : 32058020

Commercial URLhttps://linkinghub.elsevier.com/retrieve/pii/S875632822030048X

ISSN of the journal1873-2763

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Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension

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