This is an illustration of a case of “Baboon Syndrome” related to the use of Amoxicilin. “Baboon syndrome”, or symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) as it is more correctly termed, is a rare type IV hypersensitivity reaction causing a maculopapular rash. It is an unusual complication of several medications with Amoxicillin and other beta lactam antibiotics accounting for about half of cases. Given the frequent use of this antibiotic, it is important that clinicians recognize this side effect arising from this treatment.