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PEACE V – Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM): a study protocol for a randomized controlled phase II trial

Published inBMC Cancer, vol. 20, no. 1, 406
Publication date2020
Abstract

Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this moment, there are no specific treatment recommendations for patients with limited nodal recurrences and different locoregional treatment approaches are currently being used, mostly by means of metastasis-directed therapies (MDT): salvage lymph node dissection (sLND) or stereotactic body radiotherapy (SBRT). Since the majority of patients treated with MDT relapse within 2 years in adjacent lymph node regions, with an estimated median time to progression of 12-18 months, combining MDT with whole pelvic radiotherapy (WPRT) may improve oncological outcomes in these patients. The aim of this prospective multicentre randomized controlled phase II trial is to assess the impact of the addition of WPRT to MDT and short-term androgen deprivation therapy (ADT) on metastasis-free survival (MFS) in the setting of oligorecurrent pelvic nodal recurrence.

Keywords
  • Androgen deprivation therapy
  • Metastasis-directed therapy
  • Oligometastases
  • Oligorecurrence
  • Prostate cancer
  • Quality of life
  • Salvage lymph node dissection
  • Stereotactic body radiotherapy
  • Survival
  • Whole pelvic radiotherapy
Citation (ISO format)
DE BRUYCKER, A. et al. PEACE V – Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM): a study protocol for a randomized controlled phase II trial. In: BMC Cancer, 2020, vol. 20, n° 1, p. 406. doi: 10.1186/s12885-020-06911-4
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Journal ISSN1471-2407
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