Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9

Dreano, Elise; Bacchetta, Marc; Simonin, Juliette Lynn; Galmiche, Louise; Usal, Claire; Slimani, Lotfi; Sadoine, Jérémy; Tesson, Laurent; Anegon, Ignacio; Concordet, Jean-Paul; Hatton, Aurélie; Vignaud, Lucile; Tondelier, Danielle; Sermet-Gaudelus, Isabelle; Chanson, Marc; Cottart, Charles-Henry

doi:10.1002/ame2.12091

Scientific article

Open access

English

Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9

ContributorsDreano, Elise; Bacchetta, Marc; Simonin, Juliette Lynn; Galmiche, Louise; Usal, Claire; Slimani, Lotfi; Sadoine, Jérémy; Tesson, Laurent; Anegon, Ignacio; Concordet, Jean-Paul; Hatton, Aurélie; Vignaud, Lucile; Tondelier, Danielle; Sermet-Gaudelus, Isabelle; Chanson, Marc

; Cottart, Charles-Henry

Published inAnimal Models and Experimental Medicine, vol. 2, no. 4, p. 297-311

Publication date2019

Abstract

Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.

Keywords

CFTR channel activity
CFTR modulators
Animal models
Cystic fibrosis
Primary cultures
Rat

Affiliation

Research group

Mucoviscidose et jonctions communicantes (229)

Funding

Autre - Vaincre la Mucoviscidose
Autre - CFCH

Citation (ISO format)

DREANO, Elise et al. Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9. In: Animal Models and Experimental Medicine, 2019, vol. 2, n° 4, p. 297–311. doi: 10.1002/ame2.12091

Article (Published version)

CC BY

Identifiers

PID : unige:136664
DOI : 10.1002/ame2.12091
PMID : 31942562

Commercial URLhttps://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12091

ISSN of the journal2576-2095

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Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9

Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.

Technical informations