Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

Kirschner, Matthias; Cathomas, Flurin; Manoliu, Andrei; Habermeyer, Benedikt; Simon, Joe J; Seifritz, Erich; Tobler, Philippe N; Kaiser, Stefan

doi:10.1017/S0033291719000801

Scientific article

English

Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

ContributorsKirschner, Matthias; Cathomas, Flurin; Manoliu, Andrei; Habermeyer, Benedikt; Simon, Joe J; Seifritz, Erich; Tobler, Philippe N; Kaiser, Stefan

Published inPsychological Medicine, vol. 50, no. 6, p. 936-947

Publication date2020

Abstract

Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood.

Keywords

Apathy
Monetary Incentive Delay Task
Bipolar disorder
Diminished expression
Euthymic
FMRI
Negative symptoms
Reward anticipation
Striatum
Transdiagnostic

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Psychopathologie clinique et expérimentale (987)

Funding

Swiss National Science Foundation - Combining dimensional and neuroimaging approaches to the negative symptoms of schizophrenia [140351]
Swiss National Science Foundation - P00P1_150739, and PP00P1_00014_165884
Swiss National Science Foundation - Did you unlearn to experience pleasure? Towards a multimodal computational biomarker for the anhedonia dimension in depression [178107]

Citation (ISO format)

KIRSCHNER, Matthias et al. Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia. In: Psychological Medicine, 2020, vol. 50, n° 6, p. 936–947. doi: 10.1017/S0033291719000801

Article (Published version)

Identifiers

PID : unige:136535
DOI : 10.1017/S0033291719000801
PMID : 30994080

Journal ISSN1469-8978

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Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood.

Technical informations