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Title

International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation

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Published in Pediatric Transplantation. 2019, vol. 23, no. 1, e13317
Abstract In pediatric LT, anticoagulants and antiplatelet agents are regularly used to reduce the risk of vascular thrombosis. As evidence for optimal strategy is lacking, local practices vary greatly. The present survey aimed to compile an international overview of anticoagulation and antiplatelet strategies in pediatric LT. An online survey was sent to 98 pediatric LT centers in North and South America, Europe, Asia, and Australia. Twenty-four centers answered the survey. 20/24 (83%) use some sort of anticoagulation and antiplatelet therapy, yielding 20 different strategies. Perioperative vascular problems, size of the hepatic artery, and patient weight were the most frequent determinants of changes in anticoagulant and antiplatelet strategy. Early HAT rates were reported to be 5% or less in 79% of responding centers. Anticoagulation and antiplatelet strategies were not significantly associated with early HAT rates (P = 0.63), or with the number of pediatric LTs performed per year and center (P = 0.92). Internationally, there is a wide variety in anticoagulation and antiplatelet strategies after pediatric LT. Efforts must be made to design a prospective multicentric trial to identify the optimal antithrombotic strategy.
Keywords Anticoagulants/therapeutic useChildDrug Administration ScheduleHealth Care SurveysHepatic ArteryHumansLiver TransplantationPlatelet Aggregation Inhibitors/therapeutic usePostoperative Complications/prevention & controlPractice PatternsPhysicians'/statistics & numerical dataThrombosis/etiology/prevention & controlTreatment OutcomeAnticoagulationHepatic artery thrombosisPediatric liver transplantation
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PMID: 30393923
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Article (Published version) (409 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Appendix (53 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research groups Recherche clinique en chirurgie pédiatrique (886)
Oncologie et hématologie pédiatriques (907)
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CALINESCU-TULEASCA, Ana Maria et al. International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation. In: Pediatric Transplantation, 2019, vol. 23, n° 1, p. e13317. doi: 10.1111/petr.13317 https://archive-ouverte.unige.ch/unige:136389

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Deposited on : 2020-06-03

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