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Scientific article
English

International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation

Contributors

Calinescu-Tuleasca, Ana Maria; Karam, Oliver Laurent; Wilde, James Carl Henri; Ansari Djaberi, Marc Georges; Mclin, Valérie Anne; Wildhaber, Barbara

Published in

Pediatric Transplantation, vol. 23, no. 1, e13317

Publication date

2019

Abstract

In pediatric LT, anticoagulants and antiplatelet agents are regularly used to reduce the risk of vascular thrombosis. As evidence for optimal strategy is lacking, local practices vary greatly. The present survey aimed to compile an international overview of anticoagulation and antiplatelet strategies in pediatric LT. An online survey was sent to 98 pediatric LT centers in North and South America, Europe, Asia, and Australia. Twenty-four centers answered the survey. 20/24 (83%) use some sort of anticoagulation and antiplatelet therapy, yielding 20 different strategies. Perioperative vascular problems, size of the hepatic artery, and patient weight were the most frequent determinants of changes in anticoagulant and antiplatelet strategy. Early HAT rates were reported to be 5% or less in 79% of responding centers. Anticoagulation and antiplatelet strategies were not significantly associated with early HAT rates (P = 0.63), or with the number of pediatric LTs performed per year and center (P = 0.92). Internationally, there is a wide variety in anticoagulation and antiplatelet strategies after pediatric LT. Efforts must be made to design a prospective multicentric trial to identify the optimal antithrombotic strategy.

Keywords

  • Anticoagulants/therapeutic use
  • Child
  • Drug Administration Schedule
  • Health Care Surveys
  • Hepatic Artery
  • Humans
  • Liver Transplantation
  • Platelet Aggregation Inhibitors/therapeutic use
  • Postoperative Complications/prevention & control
  • Practice Patterns
  • Physicians'/statistics & numerical data
  • Thrombosis/etiology/prevention & control
  • Treatment Outcome
  • Anticoagulation
  • Hepatic artery thrombosis
  • Pediatric liver transplantation

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

CALINESCU-TULEASCA, Ana Maria et al. International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation. In: Pediatric Transplantation, 2019, vol. 23, n° 1, p. e13317. doi: 10.1111/petr.13317

Main files (1)

Article (Published version)

Secondary files (1)

Appendix

Identifiers

Journal ISSN

1397-3142
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Technical informations

Creation

11/11/2019 16:15:00

First validation

11/11/2019 16:15:00

Update

13/10/2025 17:21:43

Status update

15/03/2023 22:01:52

Last indexation

29/10/2026 12:20:10
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