Effects of PDE-5 Inhibition on the Cardiopulmonary System After 2 or 4&nbsp;Weeks of Chronic Hypoxia

Nydegger, Coline; Corno, Antonio F; von Segesser, Ludwig K; Beghetti, Maurice; Samaja, Michele; Milano, Giuseppina

doi:10.1007/s10557-019-06887-9

Scientific article

English

Effects of PDE-5 Inhibition on the Cardiopulmonary System After 2 or 4 Weeks of Chronic Hypoxia

ContributorsNydegger, Coline; Corno, Antonio F; von Segesser, Ludwig K; Beghetti, Maurice; Samaja, Michele; Milano, Giuseppina

Published inCardiovascular Drugs and Therapy, vol. 33, no. 4, p. 407-414

Publication date2019

Abstract

In pulmonary hypertension (PH), hypoxia represents both an outcome and a cause of exacerbation. We addressed the question whether hypoxia adaptation might affect the mechanisms underlying PH alleviation through phosphodiesterase-5 (PDE5) inhibition.

Keywords

Chronic hypoxia
Adaptation
Phosphodiesterase-5 inhibition
Pulmonary angiogenesis
Right-ventricle hypertrophy

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

L'hypertension pulmonaire (pédiatrie) (228)

Funding

Swiss National Science Foundation - 310000-110058

Citation (ISO format)

NYDEGGER, Coline et al. Effects of PDE-5 Inhibition on the Cardiopulmonary System After 2 or 4 Weeks of Chronic Hypoxia. In: Cardiovascular Drugs and Therapy, 2019, vol. 33, n° 4, p. 407–414. doi: 10.1007/s10557-019-06887-9

Article (Published version)

CC BY

Identifiers

PID : unige:136380
DOI : 10.1007/s10557-019-06887-9
PMID : 31264002

Additional URL for this publicationhttps://link.springer.com/article/10.1007%2Fs10557-019-06887-9

Journal ISSN0920-3206

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Creation19/11/2019 14:27:00

First validation19/11/2019 14:27:00

Update15/03/2023 22:01:42

Status update15/03/2023 22:01:42

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Effects of PDE-5 Inhibition on the Cardiopulmonary System After 2 or 4 Weeks of Chronic Hypoxia

In pulmonary hypertension (PH), hypoxia represents both an outcome and a cause of exacerbation. We addressed the question whether hypoxia adaptation might affect the mechanisms underlying PH alleviation through phosphodiesterase-5 (PDE5) inhibition.

Technical informations