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Scientific article
English

Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study

Published inAging Clinical and Experimental Research, vol. 32, no. 5, p. 817-826
Publication date2020
Abstract

Background: Alzheimer's Disease (AD) is a multifactorial disorder driven by genetic and modifiable lifestyle risk factors. Lifestyle primary prevention initiatives may reduce the prevalence and incidence of dementia in older adults. Objectives: The E.Mu.N.I study is a randomized controlled trial investigating the effect of multilevel non-pharmacologic interventions on cognitive performances (primary outcome) and structural and vascular brain MRI markers (secondary outcome), as well as markers of brain functional connectivity change (exploratory outcome), in older adults with subjective memory decline (SMD). Here, we present the study design and the baseline features of the sample.

Keywords
  • Alzheimer's disease
  • Neuroimaging
  • Non-pharmacologic interventions
  • Primary prevention
  • Subjective cognitive decline
Citation (ISO format)
ROLANDI, Elena et al. Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study. In: Aging Clinical and Experimental Research, 2020, vol. 32, n° 5, p. 817–826. doi: 10.1007/s40520-019-01403-3
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ISSN of the journal1594-0667
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