The Adamello intrusive suite is a composite batholith in Northern Italy, with an estimated 2000km3 volume, assembled incrementally over a time span of 10 to 12 million years. The history of crystallization has been studied in detail through laser ablation ICP-MS and SIMS U-Pb geochronology of zircon, which records prolonged crystallization of each of the different intrusive units at mid-crustal levels between 43.47 and 33.16 Ma. The magmas were episodically extracted from this storage area and ascended to the final intrusion level at ~6 km paleo-depth. Each batch of melt cooled very rapidly down to the ambient temperature of 250°C, evidenced by distinct cooling paths recorded by amphibole, biotite and K-feldspar 40Ar/39Ar dates. The magma source area was moving from SW to NE with time, causing increasing thermal maturity in the mid-crustal reservoir. The resulting temporal trend of higher degrees of crustal assimiliation in the course of the evolution of the magmatic system can be traced through Hf and O isotopes in zircon. Rough estimates of magma emplacement rates (‘magma flux') yield very low values in the range of 10-4km3/yr, typical of mid-to-upper crustal plutons and increase with time. Although we cannot discern a decrease of magma flux from our own data, we anticipate that a dramatic decrease of magma flux between 33 and 31Ma along the northern contact lead to cessation of magma emplacement.