Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells

Madelon, Natacha; Montanari, Elisa; Gruaz, Lyssia; Pimenta, Joël; Muller, Yannick; Buehler, Leo Hans; Puga Yung, Gisella; Seebach, Jorg Dieter

doi:10.1111/xen.12584

Scientific article

English

Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells

ContributorsMadelon, Natacha; Montanari, Elisa; Gruaz, Lyssia; Pimenta, Joël; Muller, Yannick; Buehler, Leo Hans; Puga Yung, Gisella

; Seebach, Jorg Dieter

Published inXenotransplantation, e12584

Publication date2020

Abstract

Tolerogenic dendritic cells (DCs) represent a promising approach to promote transplantation tolerance. In this study, the potential of autologous bone marrow (BM)-derived murine DC to protect rat-to-mouse islets xenografts was analyzed.

Affiliation entities

Research groups

Cellules NK et récepteurs FcyR dans l'auto-immunité et le rejet de xénotransplantation (856)

Funding

Swiss National Science Foundation - 159594.1
Swiss National Science Foundation - Transgenic strategies to overcome cellular rejection in pig-to-human xenotransplantation [138376]

Citation (ISO format)

MADELON, Natacha et al. Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells. In: Xenotransplantation, 2020, p. e12584. doi: 10.1111/xen.12584

Article (Published version)

Identifiers

PID : unige:136240
DOI : 10.1111/xen.12584
PMID : 31984564

Journal ISSN0908-665X

345views

1downloads

Creation19/02/2020 15:09:00

First validation19/02/2020 15:09:00

Update09/01/2025 10:26:27

Status update09/01/2025 10:26:27

Last indexation09/01/2025 10:30:48

Archive ouverte UNIGE

Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells

Tolerogenic dendritic cells (DCs) represent a promising approach to promote transplantation tolerance. In this study, the potential of autologous bone marrow (BM)-derived murine DC to protect rat-to-mouse islets xenografts was analyzed.

Technical informations