Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells

Madelon, Natacha; Montanari, Elisa; Gruaz, Lyssia; Pimenta, Joël; Muller, Yannick; Buehler, Leo Hans; Puga Yung, Gisella; Seebach, Jorg Dieter

doi:10.1111/xen.12584

Scientific article

English

Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells

ContributorsMadelon, Natacha; Montanari, Elisa; Gruaz, Lyssia; Pimenta, Joël; Muller, Yannick; Buehler, Leo Hans; Puga Yung, Gisella; Seebach, Jorg Dieter

Published inXenotransplantation, e12584

Publication date2020

Abstract

Tolerogenic dendritic cells (DCs) represent a promising approach to promote transplantation tolerance. In this study, the potential of autologous bone marrow (BM)-derived murine DC to protect rat-to-mouse islets xenografts was analyzed.

Affiliation

Research group

Laboratoire d'immunologie translationnelle (856)

Funding

Swiss National Science Foundation - 310030_159594.1
Swiss National Science Foundation - Transgenic strategies to overcome cellular rejection in pig-to-human xenotransplantation [320030_138376]

Citation (ISO format)

MADELON, Natacha et al. Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells. In: Xenotransplantation, 2020, p. e12584. doi: 10.1111/xen.12584

Article (Published version)

Identifiers

PID : unige:136240
DOI : 10.1111/xen.12584
PMID : 31984564

ISSN of the journal0908-665X

250views

1downloads

Creation02/19/2020 3:09:00 PM

First validation02/19/2020 3:09:00 PM

Update time03/15/2023 9:59:18 PM

Status update03/15/2023 9:59:18 PM

Last indexation01/17/2024 9:54:45 AM

Archive ouverte UNIGE

Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells

Tolerogenic dendritic cells (DCs) represent a promising approach to promote transplantation tolerance. In this study, the potential of autologous bone marrow (BM)-derived murine DC to protect rat-to-mouse islets xenografts was analyzed.

Technical informations