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Scientific article
English

Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Published inAmerican Journal of Transplantation, vol. 19, no. 11, p. 3162-3175
Publication date2019
Abstract

Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow-up. CD24hi CD38hi transitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hi CD38hi transitional B cells specifically secrete IL-10 and express CD9. Thus, patients with a total CD9+ B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL-10-secreting CD24hi CD38hi transitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9-expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long-term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome-free survival.

Keywords
  • B cell biology
  • Basic (laboratory) research/science
  • Biomarker
  • Bronchiolitis obliterans (BOS)
  • Lung transplantation/pulmonology
  • Translational research/science
Citation (ISO format)
BROSSEAU, Carole et al. Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation. In: American Journal of Transplantation, 2019, vol. 19, n° 11, p. 3162–3175. doi: 10.1111/ajt.15532
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Article (Published version)
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Identifiers
ISSN of the journal1600-6135
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Creation11/04/2019 11:20:00 AM
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