Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection

Carlisle, Louisa A; Turk, Teja; Kusejko, Katharina; Metzner, Karin J; Leemann, Christine; Schenkel, Corinne D; Bachmann, Nadine; Posada, Susana; Beerenwinkel, Niko; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Perreau, Matthieu; Braun, Dominique L; Rauch, Andri; Calmy, Alexandra; Cavassini, Matthias; Battegay, Manuel; Vernazza, Pietro; Bernasconi, Enos; Günthard, Huldrych F; Kouyos, Roger D

doi:10.1093/infdis/jiz094

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Title		Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection
Authors		Carlisle, Louisa A Turk, Teja Kusejko, Katharina Metzner, Karin J Leemann, Christine Schenkel, Corinne D Bachmann, Nadine Posada, Susana Beerenwinkel, Niko Böni, Jürg Yerly Ferrillo, Sabine Klimkait, Thomas Perreau, Matthieu Braun, Dominique L Rauch, Andri Calmy, Alexandra Cavassini, Matthias Battegay, Manuel Vernazza, Pietro Bernasconi, Enos Günthard, Huldrych F Kouyos, Roger D show all authors [1 - 22]
Collaboration		Swiss HIV Cohort Study
Published in		The Journal of infectious diseases. 2019, vol. 220, no. 2, p. 254-265
Abstract		Human immunodeficiency virus type 1 (HIV-1) genetic diversity increases over the course of infection and can be used to infer the time since infection and, consequently, infection recency, which are crucial for HIV-1 surveillance and the understanding of viral pathogenesis.
Keywords		HIV-1 — Diversity — Infection recency — Next-generation sequencing — Time since infection
Identifiers		DOI: 10.1093/infdis/jiz094 PMID: 30835266
Full text		Article (Published version) (3.1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research groups		Groupe Laurent Kaiser (virologie clinique) (668) VIH/SIDA (930)
Projects		Swiss National Science Foundation: BSSGI0_155851 Swiss National Science Foundation: 177499
Citation (ISO format)		CARLISLE, Louisa A et al. Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection. In: The Journal of Infectious Diseases, 2019, vol. 220, n° 2, p. 254-265. doi: 10.1093/infdis/jiz094 https://archive-ouverte.unige.ch/unige:136095