Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection

Carlisle, Louisa A; Turk, Teja; Kusejko, Katharina; Metzner, Karin J; Leemann, Christine; Schenkel, Corinne D; Bachmann, Nadine; Posada, Susana; Beerenwinkel, Niko; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Perreau, Matthieu; Braun, Dominique L; Rauch, Andri; Calmy, Alexandra; Cavassini, Matthias; Battegay, Manuel; Vernazza, Pietro; Bernasconi, Enos; Günthard, Huldrych F; Kouyos, Roger D; Swiss HIV Cohort Study

doi:10.1093/infdis/jiz094

Scientific article

English

Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection

Published inThe Journal of Infectious Diseases, vol. 220, no. 2, p. 254-265

Publication date2019

Abstract

Human immunodeficiency virus type 1 (HIV-1) genetic diversity increases over the course of infection and can be used to infer the time since infection and, consequently, infection recency, which are crucial for HIV-1 surveillance and the understanding of viral pathogenesis.

Keywords

HIV-1
Diversity
Infection recency
Next-generation sequencing
Time since infection

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Funding

Swiss National Science Foundation - Using transmission networks for assessing and guiding prevention efforts in hiv [155851]
Swiss National Science Foundation - 177499

Citation (ISO format)

CARLISLE, Louisa A et al. Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection. In: The Journal of Infectious Diseases, 2019, vol. 220, n° 2, p. 254–265. doi: 10.1093/infdis/jiz094

Article (Published version)

Identifiers

PID : unige:136095
DOI : 10.1093/infdis/jiz094
PMID : 30835266

Journal ISSN0022-1899

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Viral diversity based on next-generation sequencing of HIV-1 provides precise estimates of infection recency and time since infection

Human immunodeficiency virus type 1 (HIV-1) genetic diversity increases over the course of infection and can be used to infer the time since infection and, consequently, infection recency, which are crucial for HIV-1 surveillance and the understanding of viral pathogenesis.

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