en
Scientific article
English

A systematic phylogenetic approach to study the interaction of HIV-1 with coinfections, noncommunicable diseases, and opportunistic diseases

Published inThe Journal of Infectious Diseases, vol. 220, no. 2, p. 244-253
Publication date2019
Abstract

To systematically test whether coinfections spread along the HIV-1 transmission network and whether similarities in HIV-1 genomes predict AIDS-defining illnesses and comorbidities, we analyzed the distribution of these variables on the HIV phylogeny of the densely sampled Swiss HIV Cohort Study. By combining different statistical methods, we could detect, quantify, and explain the clustering of diseases. Infectious conditions such as hepatitis C, but also Kaposi sarcoma, clustered significantly, suggesting transmission of these infections along the HIV-1 transmission network. The clustering of patients with neurocognitive complaints could not be completely explained by the clustering of patients with similar demographic risk factors, which suggests a potential impact of viral genetics. In summary, the consistent and robust signal for coinfections and comorbidities highlights the strong interaction of HIV-1 and other infections and shows the potential of combining phylogenetic methods to identify disease traits that are likely to be related to virus genetic factors.

Keywords
  • HIV
  • Coinfections
  • Comorbidities
  • Opportunistic infections
  • Phylogenetic analysis
Funding
  • Swiss National Science Foundation - BSSGI0_155851, 179571
  • Swiss National Science Foundation - 177499
Citation (ISO format)
KUSEJKO, Katharina et al. A systematic phylogenetic approach to study the interaction of HIV-1 with coinfections, noncommunicable diseases, and opportunistic diseases. In: The Journal of Infectious Diseases, 2019, vol. 220, n° 2, p. 244–253. doi: 10.1093/infdis/jiz093
Main files (1)
Article (Published version)
accessLevelRestricted
Secondary files (1)
Identifiers
ISSN of the journal0022-1899
231views
0downloads

Technical informations

Creation11/05/2019 4:01:00 PM
First validation11/05/2019 4:01:00 PM
Update time03/15/2023 9:57:40 PM
Status update03/15/2023 9:57:39 PM
Last indexation01/17/2024 9:52:41 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack