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Title

A systematic phylogenetic approach to study the interaction of HIV-1 with coinfections, noncommunicable diseases, and opportunistic diseases

Authors
Kusejko, Katharina
Bachmann, Nadine
Braun, Dominique L
Hampel, Benjamin
Battegay, Manuel
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Collaboration
Published in The Journal of Infectious Diseases. 2019, vol. 220, no. 2, p. 244-253
Abstract To systematically test whether coinfections spread along the HIV-1 transmission network and whether similarities in HIV-1 genomes predict AIDS-defining illnesses and comorbidities, we analyzed the distribution of these variables on the HIV phylogeny of the densely sampled Swiss HIV Cohort Study. By combining different statistical methods, we could detect, quantify, and explain the clustering of diseases. Infectious conditions such as hepatitis C, but also Kaposi sarcoma, clustered significantly, suggesting transmission of these infections along the HIV-1 transmission network. The clustering of patients with neurocognitive complaints could not be completely explained by the clustering of patients with similar demographic risk factors, which suggests a potential impact of viral genetics. In summary, the consistent and robust signal for coinfections and comorbidities highlights the strong interaction of HIV-1 and other infections and shows the potential of combining phylogenetic methods to identify disease traits that are likely to be related to virus genetic factors.
Keywords HIVCoinfectionsComorbiditiesOpportunistic infectionsPhylogenetic analysis
Identifiers
PMID: 30835292
Full text
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Supplemental data (640 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Groupe Laurent Kaiser (virologie clinique) (668)
VIH/SIDA (930)
Projects
FNS: BSSGI0_155851, 179571
FNS: 177499
Citation
(ISO format)
KUSEJKO, Katharina et al. A systematic phylogenetic approach to study the interaction of HIV-1 with coinfections, noncommunicable diseases, and opportunistic diseases. In: The Journal of Infectious Diseases, 2019, vol. 220, n° 2, p. 244-253. doi: 10.1093/infdis/jiz093 https://archive-ouverte.unige.ch/unige:136094

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Deposited on : 2020-05-24

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