Emergence of drug resistance in the Swiss HIV Cohort Study under potent antiretroviral therapy is observed in socially disadvantaged patients

Abela, Irene A; Scherrer, Alexandra U; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Perreau, Matthieu; Hirsch, Hans H; Furrer, Hansjakob; Calmy, Alexandra; Schmid, Patrick; Cavassini, Matthias; Bernasconi, Enos; Günthard, Huldrych F; Swiss HIV Cohort Study

doi:10.1093/cid/ciz178

Scientific article

English

Emergence of drug resistance in the Swiss HIV Cohort Study under potent antiretroviral therapy is observed in socially disadvantaged patients

ContributorsAbela, Irene A; Scherrer, Alexandra U; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Perreau, Matthieu; Hirsch, Hans H; Furrer, Hansjakob; Calmy, Alexandra

; Schmid, Patrick; Cavassini, Matthias; Bernasconi, Enos; Günthard, Huldrych F; Swiss HIV Cohort Study

Published inClinical Infectious Diseases, vol. 70, no. 2, p. 297-303

Publication date2020

Abstract

The rate of acquired HIV-1 drug resistance (ADR) has fallen dramatically since introduction of combined antiretroviral therapy (cART) in Switzerland. However, clinical experience indicates that there are still patients at risk of newly acquiring drug resistance despite having access to cART. Here, we characterized risk factors for ADR, in order to improve patient care, prevent emergence of drug resistance, and treatment failure.

Keywords

HIV-1 drug resistance
Antiretroviral therapy
Risk factors
Socioeconomic factors

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Funding

Swiss National Science Foundation - 179 571
Swiss National Science Foundation - 148522

Citation (ISO format)

ABELA, Irene A et al. Emergence of drug resistance in the Swiss HIV Cohort Study under potent antiretroviral therapy is observed in socially disadvantaged patients. In: Clinical Infectious Diseases, 2020, vol. 70, n° 2, p. 297–303. doi: 10.1093/cid/ciz178

Article (Published version)

Identifiers

PID : unige:136093
DOI : 10.1093/cid/ciz178
PMID : 30843028

Journal ISSN1058-4838

377views

3downloads

Creation05/11/2019 16:05:00

First validation05/11/2019 16:05:00

Update09/02/2026 15:30:13

Status update09/02/2026 15:30:13

Last indexation09/02/2026 15:35:05

Archive ouverte UNIGE

Emergence of drug resistance in the Swiss HIV Cohort Study under potent antiretroviral therapy is observed in socially disadvantaged patients

Technical informations