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Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.

Bachmann, Nadine
von Siebenthal, Chantal
Vongrad, Valentina
Turk, Teja
Neumann, Kathrin
Beerenwinkel, Niko
Bogojeska, Jasmina
Fellay, Jaques
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Published in Nature communications. 2019, vol. 10, no. 1, 3193
Abstract The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
PMID: 31324762
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
Swiss National Science Foundation: 33CS30_177499
Swiss National Science Foundation: 324730B_179571
Swiss National Science Foundation: 310030_141067
Swiss National Science Foundation: PZ00P3_142411
Swiss National Science Foundation: BSSGI0_155851
(ISO format)
BACHMANN, Nadine et al. Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART. In: Nature Communications, 2019, vol. 10, n° 1, p. 3193. doi: 10.1038/s41467-019-10884-9 https://archive-ouverte.unige.ch/unige:136091

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Deposited on : 2020-05-24

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