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Scientific article
Open access
English

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Published inNature Communications, vol. 10, no. 1, 3193
Publication date2019
Abstract

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

Citation (ISO format)
BACHMANN, Nadine et al. Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART. In: Nature Communications, 2019, vol. 10, n° 1, p. 3193. doi: 10.1038/s41467-019-10884-9
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ISSN of the journal2041-1723
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Creation11/05/2019 4:19:00 PM
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