UNIGE document Scientific Article
previous document  unige:136091  next document
add to browser collection
Title

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.

Authors
Bachmann, Nadine
von Siebenthal, Chantal
Vongrad, Valentina
Turk, Teja
Neumann, Kathrin
Beerenwinkel, Niko
Bogojeska, Jasmina
Fellay, Jaques
show hidden authors show all authors [1 - 26]
Collaboration
Published in Nature communications. 2019, vol. 10, no. 1, 3193
Abstract The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
Identifiers
PMID: 31324762
Full text
Structures
Research group Groupe Laurent Kaiser (virologie clinique) (668)
Projects
FNS: 33CS30_177499
FNS: 324730B_179571
FNS: 310030_141067/1
FNS: PZ00P3-142411
FNS: BSSGI0_155851
Citation
(ISO format)
BACHMANN, Nadine et al. Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART. In: Nature Communications, 2019, vol. 10, n° 1, p. 3193. doi: 10.1038/s41467-019-10884-9 https://archive-ouverte.unige.ch/unige:136091

128 hits

47 downloads

Update

Deposited on : 2020-05-24

Export document
Format :
Citation style :