Consensus statement from 2nd International Conference on Controversies in Vitamin D

Giustina, A.; Adler, R. A.; Binkley, N.; Bollerslev, J.; Bouillon, R.; Dawson-Hughes, B.; Ebeling, P. R.; Feldman, D.; Formenti, A. M.; Lazaretti-Castro, M.; Marcocci, C.; Rizzoli, René; Sempos, C. T.; Bilezikian, J. P.

doi:10.1007/s11154-019-09532-w

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Title		Consensus statement from 2nd International Conference on Controversies in Vitamin D
Authors		Giustina, A. Adler, R. A. Binkley, N. Bollerslev, J. Bouillon, R. Dawson-Hughes, B. Ebeling, P. R. Feldman, D. Formenti, A. M. Lazaretti-Castro, M. Marcocci, C. Rizzoli, René Sempos, C. T. Bilezikian, J. P. show all authors [1 - 14]
Published in		Reviews in Endocrine and Metabolic Disorders. 2020, vol. 21, no. 1, p. 89-116
Abstract		The 2nd International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Definitions of vitamin D nutritional status (i.e. sufficiency, insufficiency and deficiency) were also revisited. New areas were reviewed, including vitamin D threshold values and how they should be defined in the context of specific diseases, sources of vitamin D and risk factors associated with vitamin D deficiency. Non-skeletal aspects related to vitamin D were also discussed, including the reproductive system, neurology, chronic kidney disease and falls. The therapeutic role of vitamin D and findings from recent clinical trials were also addressed. The topics were considered by 3 focus groups and divided into three main areas: 1) "Laboratory": assays and threshold values to define vitamin D status; 2) "Clinical": sources of vitamin D and risk factors and role of vitamin D in non-skeletal disease and 3) "Therapeutics": controversial issues on observational studies and recent randomized controlled trials. In this report, we present a summary of our findings.
Keywords		Extra-skeletal effects — Food — Fractures — Osteoporosis — Skin — Vitamin D
Identifiers		DOI: 10.1007/s11154-019-09532-w PMID: 32180081
Full text		Article (Published version) (715 Kb) - Free access Other version: http://link.springer.com/10.1007/s11154-019-09532-w
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Génétique des ostéoporoses (544)
Citation (ISO format)		GIUSTINA, A. et al. Consensus statement from 2nd International Conference on Controversies in Vitamin D. In: Reviews in Endocrine and Metabolic Disorders, 2020, vol. 21, n° 1, p. 89-116. doi: 10.1007/s11154-019-09532-w https://archive-ouverte.unige.ch/unige:135157