Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies

Huber, Maria; Beyer, Leonie; Prix, Catharina; Schönecker, Sonja; Palleis, Carla; Rauchmann, Boris‐Stephan; Morbelli, Silvia; Chincarini, Andrea; Bruffaerts, Rose; Vandenberghe, Rik; Van Laere, Koen; Kramberger, Milica G.; Trost, Maja; Grmek, Marko; Garibotto, Valentina; Nicastro, Nicolas; Frisoni, Giovanni; Lemstra, Afina W.; Zande, Jessica; Pilotto, Andrea; Padovani, Alessandro; Garcia‐Ptacek, Sara; Savitcheva, Irina; Ochoa‐Figueroa, Miguel A.; Davidsson, Anette; Camacho, Valle; Peira, Enrico; Arnaldi, Dario; Bauckneht, Matteo; Pardini, Matteo; Sambuceti, Gianmario; Vöglein, Jonathan; Schnabel, Jonas; Unterrainer, Marcus; Perneczky, Robert; Pogarell, Oliver; Buerger, Katharina; Catak, Cihan; Bartenstein, Peter; Cumming, Paul; Ewers, Michael; Danek, Adrian; Levin, Johannes; Aarsland, Dag; Nobili, Flavio; Rominger, Axel; Brendel, Matthias

doi:10.1002/mds.27945

Scientific article

Open access

English

Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies

ContributorsHuber, Maria; Beyer, Leonie; Prix, Catharina; Schönecker, Sonja; Palleis, Carla; Rauchmann, Boris‐Stephan; Morbelli, Silvia; Chincarini, Andrea; Bruffaerts, Rose; Vandenberghe, Rik; Van Laere, Koen; Kramberger, Milica G.; Trost, Maja; Grmek, Marko; Garibotto, Valentina

; Nicastro, Nicolas; Frisoni, Giovanni; Lemstra, Afina W.; Zande, Jessica; Pilotto, Andrea; Padovani, Alessandro; Garcia‐Ptacek, Sara; Savitcheva, Irina; Ochoa‐Figueroa, Miguel A.; Davidsson, Anette; Camacho, Valle; Peira, Enrico; Arnaldi, Dario; Bauckneht, Matteo; Pardini, Matteo; Sambuceti, Gianmario; Vöglein, Jonathan; Schnabel, Jonas; Unterrainer, Marcus; Perneczky, Robert; Pogarell, Oliver; Buerger, Katharina; Catak, Cihan; Bartenstein, Peter; Cumming, Paul; Ewers, Michael; Danek, Adrian; Levin, Johannes; Aarsland, Dag; Nobili, Flavio; Rominger, Axel; Brendel, Matthias

Published inMovement Disorders, vol. 35, no. 4, p. 595-605

Publication date2020

Abstract

Background: Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123 I-Ioflupane brain single-photon emission computed tomography of dopamine transporter and 18 F-fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill-understood. Objective: We used the hitherto largest study cohort of combined imaging from the European consortium to elucidate the role of both biomarkers in the pathophysiological course of dementia with Lewy bodies.

Keywords

Dopamine deficiency
Glucose metabolism
Lewy body dementia
Metabolic connectivity
PET
Imaging

Affiliation

Research group

Funding

Swiss National Science Foundation - The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer's Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration [320030_169876]

Citation (ISO format)

HUBER, Maria et al. Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies. In: Movement Disorders, 2020, vol. 35, n° 4, p. 595–605. doi: 10.1002/mds.27945

Article (Published version)

CC BY-NC-ND

Identifiers

PID : unige:134860
DOI : 10.1002/mds.27945
PMID : 31840326

Commercial URLhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27945

ISSN of the journal0885-3185

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Creation04/18/2020 8:14:00 AM

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Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies

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