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Title

Evaluation of Macitentan in Patients With Eisenmenger Syndrome: Results From the Randomized, Controlled MAESTRO Study

Authors
Gatzoulis, Michael A
Landzberg, Michael
Berger, Rolf M
Efficace, Michela
Gesang, Sophie
He, Jian'guo
Papadakis, Kelly
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Published in Circulation. 2019, vol. 139, no. 1, p. 51-63
Abstract Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eisenmenger Syndrome to Restore Exercise Capacity) evaluated the efficacy and safety of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome.
Keywords AdolescentAdultAgedAged, 80 and overAntihypertensive Agents/adverse effects/therapeutic useBiomarkers/bloodChildDouble-Blind MethodDown Syndrome/complicationsEisenmenger Complex/complications/diagnostic imaging/physiopathologyEndothelin Receptor Antagonists/adverse effects/therapeutic useExercise Tolerance/drug effectsFemaleHemodynamics/drug effectsHumansHypertension, Pulmonary/diagnostic imaging/drug therapy/etiology/physiopathologyMaleMiddle AgedNatriuretic Peptide, Brain/bloodPeptide Fragments/bloodPulmonary Artery/drug effects/physiopathologyPyrimidines/adverse effects/therapeutic useRecovery of FunctionSulfonamides/adverse effects/therapeutic useTime FactorsTreatment OutcomeWalk TestYoung Adult
Identifiers
PMID: 30586694
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Structures
Research group L'hypertension pulmonaire (pédiatrie) (228)
Citation
(ISO format)
GATZOULIS, Michael A et al. Evaluation of Macitentan in Patients With Eisenmenger Syndrome: Results From the Randomized, Controlled MAESTRO Study. In: Circulation, 2019, vol. 139, n° 1, p. 51-63. doi: 10.1161/CIRCULATIONAHA.118.033575 https://archive-ouverte.unige.ch/unige:134639

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Deposited on : 2020-04-15

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