Scientific article
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English

Evaluation of Macitentan in Patients With Eisenmenger Syndrome: Results From the Randomized, Controlled MAESTRO Study

Published inCirculation, vol. 139, no. 1, p. 51-63
Publication date2019
Abstract

Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eisenmenger Syndrome to Restore Exercise Capacity) evaluated the efficacy and safety of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents/adverse effects/therapeutic use
  • Biomarkers/blood
  • Child
  • Double-Blind Method
  • Down Syndrome/complications
  • Eisenmenger Complex/complications/diagnostic imaging/physiopathology
  • Endothelin Receptor Antagonists/adverse effects/therapeutic use
  • Exercise Tolerance/drug effects
  • Female
  • Hemodynamics/drug effects
  • Humans
  • Hypertension, Pulmonary/diagnostic imaging/drug therapy/etiology/physiopathology
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain/blood
  • Peptide Fragments/blood
  • Pulmonary Artery/drug effects/physiopathology
  • Pyrimidines/adverse effects/therapeutic use
  • Recovery of Function
  • Sulfonamides/adverse effects/therapeutic use
  • Time Factors
  • Treatment Outcome
  • Walk Test
  • Young Adult
Citation (ISO format)
GATZOULIS, Michael A et al. Evaluation of Macitentan in Patients With Eisenmenger Syndrome: Results From the Randomized, Controlled MAESTRO Study. In: Circulation, 2019, vol. 139, n° 1, p. 51–63. doi: 10.1161/CIRCULATIONAHA.118.033575
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
Journal ISSN0009-7322
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494downloads

Technical informations

Creation10/28/2019 12:12:00 PM
First validation10/28/2019 12:12:00 PM
Update time03/15/2023 9:30:39 PM
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