en
Scientific article
English

Perioperative chemotherapy for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial

Published inThe Lancet, vol. 393, no. 10184, p. 1948-1957
Publication date2019
Abstract

Docetaxel-based chemotherapy is effective in metastatic gastric and gastro-oesophageal junction adenocarcinoma. This study reports on the safety and efficacy of the docetaxel-based triplet FLOT (fluorouracil plus leucovorin, oxaliplatin and docetaxel) as a perioperative therapy for patients with locally advanced, resectable tumours.

Keywords
  • Adenocarcinoma/drug therapy/pathology
  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols/administration & dosage/therapeutic use
  • Capecitabine/administration & dosage/therapeutic use
  • Cisplatin/administration & dosage/therapeutic use
  • Digestive System Surgical Procedures
  • Disease-Free Survival
  • Docetaxel/administration & dosage/therapeutic use
  • Esophagogastric Junction/pathology
  • Female
  • Fluorouracil/administration & dosage/therapeutic use
  • Humans
  • Leucovorin/administration & dosage/therapeutic use
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Oxaliplatin/administration & dosage/therapeutic use
  • Stomach Neoplasms/drug therapy/pathology
  • Treatment Outcome
Citation (ISO format)
AL-BATRAN, Salah-Eddin et al. Perioperative chemotherapy for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. In: The Lancet, 2019, vol. 393, n° 10184, p. 1948–1957. doi: 10.1016/S0140-6736(18)32557-1
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Article (Published version)
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Identifiers
ISSN of the journal0140-6736
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