In this thesis, I will discuss how focusing on prevention (primordial, primary, secondary, or tertiary) as a pediatric and adolescent gynecologist can be influential and empowering for adolescents and their families, as well as for healthcare providers. I will present topics that reflect my own research and that exemplify the challenges encountered when working at different levels of prevention. In addition I will describe how prevention at all levels can be readily incorporated into pediatric and adolescent gynecological clinical encounters. In addition, I will illustrate how prevention can be achieved through encouraging self-esteem, including positive sexuality, whether in screening or during the management of different conditions.