Fracture risk following intermission of osteoporosis therapy

Dennison, E.M.; Cooper, C.; Kanis, J.A.; Bruyère, O.; Silverman, S.; McCloskey, E.; Abrahamsen, B.; Prieto-Alhambra, D.; Ferrari, Serge Livio; IOF Epidemiology/Quality of Life Working Group

doi:10.1007/s00198-019-05002-w

Scientific article

Review

English

Fracture risk following intermission of osteoporosis therapy

ContributorsDennison, E.M.; Cooper, C.; Kanis, J.A.; Bruyère, O.; Silverman, S.; McCloskey, E.; Abrahamsen, B.; Prieto-Alhambra, D.; Ferrari, Serge Livio; IOF Epidemiology/Quality of Life Working Group

Published inOsteoporosis International, vol. 30, no. 9, p. 1733-1743

Publication date2019

Abstract

Given the widespread practice of recommending drug holidays, we reviewed the impact of medication discontinuation of two common anti-osteoporosis therapies (bisphosphonates and denosumab). Trial evidence suggests the risk of new clinical fractures, and vertebral fracture increases when osteoporosis treatment with bisphosphonates or denosumab is stopped.

Keywords

Atypical fracture
Bisphosphonates
Denosumab
Drug holiday.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Génétique des ostéoporoses (544)

Citation (ISO format)

DENNISON, E.M. et al. Fracture risk following intermission of osteoporosis therapy. In: Osteoporosis International, 2019, vol. 30, n° 9, p. 1733–1743. doi: 10.1007/s00198-019-05002-w

Article (Published version)

Identifiers

PID : unige:134040
DOI : 10.1007/s00198-019-05002-w
PMID : 31175404

Commercial URLhttp://link.springer.com/10.1007/s00198-019-05002-w

Journal ISSN0937-941X

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Creation12/12/2019 14:42:00

First validation12/12/2019 14:42:00

Update time15/03/2023 22:27:19

Status update15/03/2023 22:27:18

Last indexation31/10/2024 19:21:40

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Fracture risk following intermission of osteoporosis therapy

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