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Doctoral thesis
Open access
English

Understanding the interactions of gold nanoparticles with B lymphocytes in vitro and in vivo

ContributorsHocevar, Sandra
Defense date2020-01-28
Abstract

Nanomedicine is a promising discipline within nanotechnology, using nanoparticles for the improvement of drug delivery, diagnostics and therapy. Gold nanoparticles (GNPs) are commonly used in a variety of biomedical applications due to their highly beneficial properties. Nonetheless, the question remains regarding the possible adverse impact of GNPs on the immune cell function such is the immune response of B lymphocytes (also known as B cells). Our results showed that certain types of GNPs were able to directly interact with B cells in vitro and in vivo. Moreover, GNPs were able to modulate B cell immune function, resulting in attenuation of secretion of (pro-)inflammatory modulators as well as suppression of antigen-specific antibody production. Importantly, throughout the project, we demonstrated that GNPs are highly biocompatible with B cells. Our results provide important information that can help to evaluate the appropriateness of GNPs for biomedical applications and better predict their safety and success for future translation of GNP applications to clinical studies.

eng
Keywords
  • Gold nanoparticles
  • B lymphocytes
  • Nanotoxicology
  • Nanomedicine
Funding
  • Swiss National Science Foundation - 156871
Citation (ISO format)
HOCEVAR, Sandra. Understanding the interactions of gold nanoparticles with B lymphocytes in vitro and in vivo. 2020. doi: 10.13097/archive-ouverte/unige:133930
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Technical informations

Creation03/10/2020 2:18:00 PM
First validation03/10/2020 2:18:00 PM
Update time03/05/2024 3:21:38 PM
Status update03/05/2024 3:21:38 PM
Last indexation05/05/2024 4:38:26 PM
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