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Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach |
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Published in | Lasers in surgery and medicine. 2007, vol. 39, no. 1, p. 67-75 | |
Abstract | Photodynamic therapy (PDT) of superficial bladder cancer may cause damages to the normal surrounding bladder wall. Prevention of these is important for bladder healing. We studied the influence of photosensitizer concentration, irradiation parameters, and production of reactive oxygen species (ROS) on the photodynamically induced damage in the porcine urothelium invitro. The aim was to determine the threshold conditions for the cell survival. | |
Keywords | Aminolevulinic Acid/analogs & derivatives/therapeutic use — Animals — Cell Survival — Microscopy, Electron, Scanning — Mucous Membrane — Photobleaching — Photochemotherapy — Photosensitizing Agents/pharmacology — Protoporphyrins/pharmacology — Reactive Oxygen Species/metabolism — Soft Tissue Injuries/prevention & control — Spectrometry, Fluorescence — Swine — Urinary Bladder Neoplasms/drug therapy — Urothelium/drug effects/metabolism/pathology/radiation effects | |
Identifiers | DOI: 10.1002/lsm.20416 PMID: 17096415 | |
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Citation (ISO format) | VAUCHER, Laurent et al. Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach. In: Lasers in Surgery and Medicine, 2007, vol. 39, n° 1, p. 67-75. doi: 10.1002/lsm.20416 https://archive-ouverte.unige.ch/unige:13278 |