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Title

Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach
Authors
Vaucher, Laurent
Jichlinski, Patrice
Lange, Norbert
Ritter-Schenk, Céline
van den Bergh, Hubert
Kucera, Pavel
Published in Lasers in Surgery and Medicine. 2007, vol. 39, no. 1, p. 67-75
Abstract Photodynamic therapy (PDT) of superficial bladder cancer may cause damages to the normal surrounding bladder wall. Prevention of these is important for bladder healing. We studied the influence of photosensitizer concentration, irradiation parameters, and production of reactive oxygen species (ROS) on the photodynamically induced damage in the porcine urothelium invitro. The aim was to determine the threshold conditions for the cell survival.
Keywords Aminolevulinic Acid/analogs & derivatives/therapeutic use — Animals — Cell Survival — Microscopy, Electron, Scanning — Mucous Membrane — Photobleaching — Photochemotherapy — Photosensitizing Agents/pharmacology — Protoporphyrins/pharmacology — Reactive Oxygen Species/metabolism — Soft Tissue Injuries/prevention & control — Spectrometry, Fluorescence — Swine — Urinary Bladder Neoplasms/drug therapy — Urothelium/drug effects/metabolism/pathology/radiation effects
Identifiers
PMID: 17096415
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Citation
(ISO format) 		VAUCHER, Laurent et al. Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach. In: Lasers in Surgery and Medicine, 2007, vol. 39, n° 1, p. 67-75. doi: 10.1002/lsm.20416 https://archive-ouverte.unige.ch/unige:13278

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Deposited on : 2011-01-27

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