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Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach

Vaucher, Laurent
Jichlinski, Patrice
Ritter-Schenk, Céline
van den Bergh, Hubert
Kucera, Pavel
Published in Lasers in Surgery and Medicine. 2007, vol. 39, no. 1, p. 67-75
Abstract Photodynamic therapy (PDT) of superficial bladder cancer may cause damages to the normal surrounding bladder wall. Prevention of these is important for bladder healing. We studied the influence of photosensitizer concentration, irradiation parameters, and production of reactive oxygen species (ROS) on the photodynamically induced damage in the porcine urothelium invitro. The aim was to determine the threshold conditions for the cell survival.
Keywords Aminolevulinic Acid/analogs & derivatives/therapeutic useAnimalsCell SurvivalMicroscopy, Electron, ScanningMucous MembranePhotobleachingPhotochemotherapyPhotosensitizing Agents/pharmacologyProtoporphyrins/pharmacologyReactive Oxygen Species/metabolismSoft Tissue Injuries/prevention & controlSpectrometry, FluorescenceSwineUrinary Bladder Neoplasms/drug therapyUrothelium/drug effects/metabolism/pathology/radiation effects
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PMID: 17096415

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Deposited on : 2011-01-27

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