Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease

Ramusino, Matteo Cotta; Garibotto, Valentina; Bacchin, Ruggero; Altomare, Daniele; Dodich, Alessandra; Assal, Frédéric; Mendes Aguiar Santos, Aline; Costa, Alfredo; Tinazzi, Michele; Morbelli, Silvia D.; Bauckneht, Matteo; Picco, Agnese; Dottorini, Massimo E.; Tranfaglia, Cristina; Farotti, Lucia; Salvadori, Nicola; Moretti, Davide; Savelli, Giordano; Tarallo, Anna; Nobili, Flavio; Parapini, Maura; Cavaliere, Carlo; Salvatore, Elena; Salvatore, Marco; Boccardi, Marina; Frisoni, Giovanni

doi:10.1007/s00259-019-04466-6

Scientific article

English

Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease

Published inEuropean Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 2, p. 270-280

Publication date2020

Abstract

PURPOSE: To compare the incremental diagnostic value of amyloid-PET and CSF (Aβ42, tau, and phospho-tau) in AD diagnosis in patients with mild cognitive impairment (MCI) or mild dementia, in order to improve the definition of diagnostic algorithm.

Keywords

Alzheimer's disease
Cerebrospinal fluid
Incremental diagnostic value
Mild cognitive impairment
Positron emission tomography

Affiliation

Research group

Funding

Swiss National Science Foundation - The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer's Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration [320030_169876]

Citation (ISO format)

RAMUSINO, Matteo Cotta et al. Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer’s disease. In: European Journal of Nuclear Medicine and Molecular Imaging, 2020, vol. 47, n° 2, p. 270–280. doi: 10.1007/s00259-019-04466-6

Article (Published version)

Identifiers

PID : unige:132778
DOI : 10.1007/s00259-019-04466-6
PMID : 31388720

Commercial URLhttp://link.springer.com/10.1007/s00259-019-04466-6

ISSN of the journal1619-7070

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Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease

PURPOSE: To compare the incremental diagnostic value of amyloid-PET and CSF (Aβ42, tau, and phospho-tau) in AD diagnosis in patients with mild cognitive impairment (MCI) or mild dementia, in order to improve the definition of diagnostic algorithm.

Technical informations