en
Scientific article
English

Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study

Published inTransplant International, vol. 32, no. 1, p. 49-58
Publication date2019
Abstract

Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency [25-OH vitamin D (25-OHD) <50 nmol/l] and no deficiency (25-OHD ≥50 nmol/l) in incident infections after liver transplantation. In 135 liver transplant recipients, blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the Swiss Transplant Cohort Study database. Poisson regression was applied to address associations between vitamin D status and incident infections. Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses, vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant incidence rate ratio (IRR 1.52, 95% CI 1.08-2.15, P = 0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P = 0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections.

Keywords
  • Adult
  • Aged
  • Bacterial Infections/epidemiology
  • Female
  • Humans
  • Liver Failure/blood/surgery
  • Liver Transplantation/adverse effects
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Poisson Distribution
  • Postoperative Complications
  • Prospective Studies
  • Regression Analysis
  • Risk Factors
  • Switzerland
  • Vitamin D/blood
  • Vitamin D Deficiency/complications
  • Infections
  • Liver transplantation
  • Post-transplant care
  • Vitamin D
Funding
  • Swiss National Science Foundation - Swiss Transplant Cohort Study
Citation (ISO format)
SCHREIBER, Peter W et al. Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. In: Transplant International, 2019, vol. 32, n° 1, p. 49–58. doi: 10.1111/tri.13328
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Article (Published version)
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Identifiers
ISSN of the journal0934-0874
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