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Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study

Schreiber, Peter W
Bischoff-Ferrari, Heike A
Boggian, Katia
Fehr, Thomas
Garzoni, Christian
Hirsch, Hans H
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CollaborationWith : Chalandon, Yves / Gasche-Soccal, Paola Marina Alessandra / Lovis, Christian / Majno, Pietro / Martin, Pierre-Yves / Posfay Barbe, Clara / Toso, Christian / Villard, Jean
Published in Transplant international. 2019, vol. 32, no. 1, p. 49-58
Abstract Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency [25-OH vitamin D (25-OHD) <50 nmol/l] and no deficiency (25-OHD ≥50 nmol/l) in incident infections after liver transplantation. In 135 liver transplant recipients, blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the Swiss Transplant Cohort Study database. Poisson regression was applied to address associations between vitamin D status and incident infections. Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses, vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant incidence rate ratio (IRR 1.52, 95% CI 1.08-2.15, P = 0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P = 0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections.
Keywords AdultAgedBacterial Infections/epidemiologyFemaleHumansLiver Failure/blood/surgeryLiver Transplantation/adverse effectsMaleMiddle AgedMultivariate AnalysisPoisson DistributionPostoperative ComplicationsProspective StudiesRegression AnalysisRisk FactorsSwitzerlandVitamin D/bloodVitamin D Deficiency/complicationsInfectionsLiver transplantationPost-transplant careVitamin D
PMID: 30099788
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Research groups Groupe Gasche-Soccal Paola (958)
Interfaces Homme-machine en milieu clinique (610)
La transplantation d'îlots de Langerhans (623)
Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Quorom-sensing et gènes de virulence (301)
Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Transplantation et hépatologie (905)
Transplantation immunologie et osteoimmunologie (561)
Swiss National Science Foundation: Swiss Transplant Cohort Study
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SCHREIBER, Peter W et al. Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. In: Transplant International, 2019, vol. 32, n° 1, p. 49-58. doi: 10.1111/tri.13328 https://archive-ouverte.unige.ch/unige:132663

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Deposited on : 2020-03-20

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