Heat shock proteins (HSPs) are released in response to stress situations, such as heat, inflammation, infection. They are also involved in the tumor cell proliferation and prevention of apoptosis. Heat shock protein 105 (Hsp105/110) is a high-molecular-weight protein which has been reported in many cancer types but few studies have been carried out on oral squamous cell carcinoma (OSCC). In the current study we have focused on HSP105 expression on OSCC and evaluated their correlation with tumor clinicopathological parameters and patients' survival.