Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Kim, Min; Snowden, Stuart; Suvitaival, Tommi; Ali, Ashfaq; Merkler, David J; Ahmad, Tahmina; Westwood, Sarah; Baird, Alison; Proitsi, Petroula; Nevado-Holgado, Alejo; Hye, Abdul; Bos, Isabelle; Vos, Stephanie; Vandenberghe, Rik; Teunissen, Charlotte; Ten Kate, Mara; Scheltens, Philip; Gabel, Silvy; Meersmans, Karen; Blin, Olivier; Richardson, Jill; De Roeck, Ellen; Sleegers, Kristel; Bordet, Régis; Rami, Lorena; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Sala, Isabel; Lléo, Alberto; Peyratout, Gwendoline; Tainta, Mikel; Johannsen, Peter; Freund-Levi, Yvonne; Frölich, Lutz; Dobricic, Valerija; Engelborghs, Sebastiaan; Frisoni, Giovanni; Molinuevo, José L; Wallin, Anders; Popp, Julius; Martinez-Lage, Pablo; Bertram, Lars; Barkhof, Frederik; Ashton, Nicholas; Blennow, Kaj; Zetterberg, Henrik; Streffer, Johannes; Visser, Pieter J; Lovestone, Simon; Legido-Quigley, Cristina

doi:10.1016/j.jalz.2019.03.004

Scientific article

English

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

ContributorsKim, Min; Snowden, Stuart; Suvitaival, Tommi; Ali, Ashfaq; Merkler, David J; Ahmad, Tahmina; Westwood, Sarah; Baird, Alison; Proitsi, Petroula; Nevado-Holgado, Alejo; Hye, Abdul; Bos, Isabelle; Vos, Stephanie; Vandenberghe, Rik; Teunissen, Charlotte; Ten Kate, Mara; Scheltens, Philip; Gabel, Silvy; Meersmans, Karen; Blin, Olivier; Richardson, Jill; De Roeck, Ellen; Sleegers, Kristel; Bordet, Régis; Rami, Lorena; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Sala, Isabel; Lléo, Alberto; Peyratout, Gwendoline; Tainta, Mikel; Johannsen, Peter; Freund-Levi, Yvonne; Frölich, Lutz; Dobricic, Valerija; Engelborghs, Sebastiaan; Frisoni, Giovanni; Molinuevo, José L; Wallin, Anders; Popp, Julius; Martinez-Lage, Pablo; Bertram, Lars; Barkhof, Frederik; Ashton, Nicholas; Blennow, Kaj; Zetterberg, Henrik; Streffer, Johannes; Visser, Pieter J; Lovestone, Simon; Legido-Quigley, Cristina

Published inAlzheimer's & Dementia, vol. 15, no. 6, p. 817-827

Publication date2019

Abstract

A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.

Keywords

EMIF-AD
Alzheimer's disease
Dementia
Amyloid
Tau
CSF
Brain volume measurements
Cognitive function measurements
Metabolomics
Biomarkers

Affiliation entities

Research groups

Troubles de mémoire et maladie d'Alzeimer (935)

Citation (ISO format)

KIM, Min et al. Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort. In: Alzheimer’s & Dementia, 2019, vol. 15, n° 6, p. 817–827. doi: 10.1016/j.jalz.2019.03.004