Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer&#039;s Disease biomarker discovery cohort

Kim, Min; Snowden, Stuart; Suvitaival, Tommi; Ali, Ashfaq; Merkler, David J; Ahmad, Tahmina; Westwood, Sarah; Baird, Alison; Proitsi, Petroula; Nevado-Holgado, Alejo; Hye, Abdul; Bos, Isabelle; Vos, Stephanie; Vandenberghe, Rik; Teunissen, Charlotte; Ten Kate, Mara; Scheltens, Philip; Gabel, Silvy; Meersmans, Karen; Blin, Olivier; Richardson, Jill; De Roeck, Ellen; Sleegers, Kristel; Bordet, Régis; Rami, Lorena; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Sala, Isabel; Lléo, Alberto; Peyratout, Gwendoline; Tainta, Mikel; Johannsen, Peter; Freund-Levi, Yvonne; Frölich, Lutz; Dobricic, Valerija; Engelborghs, Sebastiaan; Frisoni, Giovanni; Molinuevo, José L; Wallin, Anders; Popp, Julius; Martinez-Lage, Pablo; Bertram, Lars; Barkhof, Frederik; Ashton, Nicholas; Blennow, Kaj; Zetterberg, Henrik; Streffer, Johannes; Visser, Pieter J; Lovestone, Simon; Legido-Quigley, Cristina

doi:10.1016/j.jalz.2019.03.004

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Title		Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
Authors		Kim, Min Snowden, Stuart Suvitaival, Tommi Ali, Ashfaq Merkler, David J Ahmad, Tahmina Westwood, Sarah Baird, Alison Proitsi, Petroula Nevado-Holgado, Alejo Hye, Abdul Bos, Isabelle Vos, Stephanie Vandenberghe, Rik Teunissen, Charlotte Ten Kate, Mara Scheltens, Philip Gabel, Silvy Meersmans, Karen Blin, Olivier Richardson, Jill De Roeck, Ellen Sleegers, Kristel Bordet, Régis Rami, Lorena Kettunen, Petronella Tsolaki, Magda Verhey, Frans Sala, Isabel Lléo, Alberto Peyratout, Gwendoline Tainta, Mikel Johannsen, Peter Freund-Levi, Yvonne Frölich, Lutz Dobricic, Valerija Engelborghs, Sebastiaan Frisoni, Giovanni Molinuevo, José L Wallin, Anders Popp, Julius Martinez-Lage, Pablo Bertram, Lars Barkhof, Frederik Ashton, Nicholas Blennow, Kaj Zetterberg, Henrik Streffer, Johannes Visser, Pieter J Lovestone, Simon Legido-Quigley, Cristina show all authors [1 - 51]
Published in		Alzheimer's & dementia. 2019, vol. 15, no. 6, p. 817-827
Abstract		A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.
Keywords		EMIF-AD — Alzheimer's disease — Dementia — Amyloid — Tau — CSF — Brain volume measurements — Cognitive function measurements — Metabolomics — Biomarkers
Identifiers		DOI: 10.1016/j.jalz.2019.03.004 PMID: 31078433
Full text		Article (Published version) (1.2 MB) - Free access Other version: https://www.sciencedirect.com/science/article/pii/S1552526019300743
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		KIM, Min et al. Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort. In: Alzheimer's & Dementia, 2019, vol. 15, n° 6, p. 817-827. doi: 10.1016/j.jalz.2019.03.004 https://archive-ouverte.unige.ch/unige:132383