Meaningful and feasible composite clinical worsening definitions in paediatric pulmonary arterial hypertension: An analysis of the TOPP registry

Beghetti, Maurice; Brand, Monika; Berger, Rolf M F; Humpl, Tilman; Wheeler, Jeremy G; Ivy, D Dunbar; Bonnet, Damien; TOPP investigators

doi:10.1016/j.ijcard.2019.04.062

Scientific article

Open access

English

Meaningful and feasible composite clinical worsening definitions in paediatric pulmonary arterial hypertension: An analysis of the TOPP registry

ContributorsBeghetti, Maurice; Brand, Monika; Berger, Rolf M F; Humpl, Tilman; Wheeler, Jeremy G; Ivy, D Dunbar; Bonnet, Damien; TOPP investigators

Published inInternational Journal of Cardiology, vol. 289, p. 110-115

Publication date2019

Abstract

Composite clinical worsening (cCW) outcomes might allow measurement of disease progression in paediatric pulmonary arterial hypertension (PAH). This TOPP registry analysis investigated three cCW outcomes and their predictive strength for lung transplantation/death.

Keywords

Clinical worsening
Paediatric PAH
Clinical endpoints
Disease worsening

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

L'hypertension pulmonaire (pédiatrie) (228)

Citation (ISO format)

BEGHETTI, Maurice et al. Meaningful and feasible composite clinical worsening definitions in paediatric pulmonary arterial hypertension: An analysis of the TOPP registry. In: International Journal of Cardiology, 2019, vol. 289, p. 110–115. doi: 10.1016/j.ijcard.2019.04.062