Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients

Cousin, Vladimir; Rougemont-Pidoux, Anne-Laure; Rubbia-Brandt, Laura; Wildhaber, Barbara; Villard, Jean; Ferrari-Lacraz, Sylvie; Mclin, Valérie Anne

doi:10.1097/TP.0000000000003099

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Title		Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients
Authors		Cousin, Vladimir Rougemont-Pidoux, Anne-Laure Rubbia-Brandt, Laura Wildhaber, Barbara Villard, Jean Ferrari-Lacraz, Sylvie Mclin, Valérie Anne
Published in		Transplantation. 2020, vol. 104, no. 8, p. 1633-1643
Abstract		The cellular infiltrate in protocol liver biopsies (PB) following pediatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about the role of inflammation and fibrosis in long-term liver allografts. We aimed to define cell types in PB and to analyze their relationship with donor specific antibodies and histological phenotype.
Keywords		Adolescent — Adult — Allografts/blood supply/immunology/pathology — Biopsy — Child — Preschool — End Stage Liver Disease/diagnosis/etiology/surgery — Female — Fibrosis — Follow-Up Studies — Graft Rejection/immunology/pathology — Graft Survival/immunology — HLA Antigens/immunology — Histocompatibility Testing/statistics & numerical data — Humans — Immunity — Cellular — Infant — Isoantibodies/analysis/immunology — Liver/blood supply/immunology/pathology — Liver Transplantation/adverse effects — Living Donors/statistics & numerical data — Macrophages/immunology — Male — Portal System/cytology/immunology — Severity of Illness Index — T-Lymphocytes/immunology — Transplant Recipients/statistics & numerical data — Transplantation — Homologous/adverse effects — Young Adult
Identifiers		DOI: 10.1097/TP.0000000000003099 PMID: 32732841
Full text		Article (Accepted version) (4 MB) - Free access Article (Published version) (877 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		Développement du tube digestif chez les vertébrés (900) Métastases du foie (657) Recherche clinique en chirurgie pédiatrique (886) Transplantation immunologie et osteoimmunologie (561)
Citation (ISO format)		COUSIN, Vladimir et al. Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients. In: Transplantation, 2020, vol. 104, n° 8, p. 1633-1643. doi: 10.1097/TP.0000000000003099 https://archive-ouverte.unige.ch/unige:131899