en
Scientific article
Open access
English

Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients

Published inTransplantation, vol. 104, no. 8, p. 1633-1643
Publication date2020
Abstract

The cellular infiltrate in protocol liver biopsies (PB) following pediatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about the role of inflammation and fibrosis in long-term liver allografts. We aimed to define cell types in PB and to analyze their relationship with donor specific antibodies and histological phenotype.

Keywords
  • Adolescent
  • Adult
  • Allografts/blood supply/immunology/pathology
  • Biopsy
  • Child
  • Preschool
  • End Stage Liver Disease/diagnosis/etiology/surgery
  • Female
  • Fibrosis
  • Follow-Up Studies
  • Graft Rejection/immunology/pathology
  • Graft Survival/immunology
  • HLA Antigens/immunology
  • Histocompatibility Testing/statistics & numerical data
  • Humans
  • Immunity
  • Cellular
  • Infant
  • Isoantibodies/analysis/immunology
  • Liver/blood supply/immunology/pathology
  • Liver Transplantation/adverse effects
  • Living Donors/statistics & numerical data
  • Macrophages/immunology
  • Male
  • Portal System/cytology/immunology
  • Severity of Illness Index
  • T-Lymphocytes/immunology
  • Transplant Recipients/statistics & numerical data
  • Transplantation
  • Homologous/adverse effects
  • Young Adult
Citation (ISO format)
COUSIN, Vladimir et al. Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients. In: Transplantation, 2020, vol. 104, n° 8, p. 1633–1643. doi: 10.1097/TP.0000000000003099
Main files (2)
Article (Accepted version)
accessLevelPublic
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1337
252views
134downloads

Technical informations

Creation03/05/2020 4:41:00 PM
First validation03/05/2020 4:41:00 PM
Update time03/15/2023 9:13:02 PM
Status update03/15/2023 9:13:01 PM
Last indexation10/19/2023 12:14:59 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack