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Title

Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients

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Published in Transplantation. 2020, vol. 104, no. 8, p. 1633-1643
Abstract The cellular infiltrate in protocol liver biopsies (PB) following pediatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about the role of inflammation and fibrosis in long-term liver allografts. We aimed to define cell types in PB and to analyze their relationship with donor specific antibodies and histological phenotype.
Keywords AdolescentAdultAllografts/blood supply/immunology/pathologyBiopsyChildPreschoolEnd Stage Liver Disease/diagnosis/etiology/surgeryFemaleFibrosisFollow-Up StudiesGraft Rejection/immunology/pathologyGraft Survival/immunologyHLA Antigens/immunologyHistocompatibility Testing/statistics & numerical dataHumansImmunityCellularInfantIsoantibodies/analysis/immunologyLiver/blood supply/immunology/pathologyLiver Transplantation/adverse effectsLiving Donors/statistics & numerical dataMacrophages/immunologyMalePortal System/cytology/immunologySeverity of Illness IndexT-Lymphocytes/immunologyTransplant Recipients/statistics & numerical dataTransplantationHomologous/adverse effectsYoung Adult
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PMID: 32732841
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Structures
Research groups Métastases du foie (657)
Transplantation immunologie et osteoimmunologie (561)
Développement du tube digestif chez les vertébrés (900)
Recherche clinique en chirurgie pédiatrique (886)
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COUSIN, Vladimir et al. Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients. In: Transplantation, 2020, vol. 104, n° 8, p. 1633-1643. doi: 10.1097/TP.0000000000003099 https://archive-ouverte.unige.ch/unige:131899

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Deposited on : 2020-03-09

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