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Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients |
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Authors | ||
Published in | Transplantation. 2020, vol. 104, no. 8, p. 1633-1643 | |
Abstract | The cellular infiltrate in protocol liver biopsies (PB) following pediatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about the role of inflammation and fibrosis in long-term liver allografts. We aimed to define cell types in PB and to analyze their relationship with donor specific antibodies and histological phenotype. | |
Keywords | Adolescent — Adult — Allografts/blood supply/immunology/pathology — Biopsy — Child — Preschool — End Stage Liver Disease/diagnosis/etiology/surgery — Female — Fibrosis — Follow-Up Studies — Graft Rejection/immunology/pathology — Graft Survival/immunology — HLA Antigens/immunology — Histocompatibility Testing/statistics & numerical data — Humans — Immunity — Cellular — Infant — Isoantibodies/analysis/immunology — Liver/blood supply/immunology/pathology — Liver Transplantation/adverse effects — Living Donors/statistics & numerical data — Macrophages/immunology — Male — Portal System/cytology/immunology — Severity of Illness Index — T-Lymphocytes/immunology — Transplant Recipients/statistics & numerical data — Transplantation — Homologous/adverse effects — Young Adult | |
Identifiers | PMID: 32732841 | |
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Research groups | Développement du tube digestif chez les vertébrés (900) Métastases du foie (657) Recherche clinique en chirurgie pédiatrique (886) Transplantation immunologie et osteoimmunologie (561) | |
Citation (ISO format) | COUSIN, Vladimir et al. Peripheral donor specific antibodies are associated with histology and cellular subtypes in protocol liver biopsies of pediatric recipients. In: Transplantation, 2020, vol. 104, n° 8, p. 1633-1643. doi: 10.1097/TP.0000000000003099 https://archive-ouverte.unige.ch/unige:131899 |