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Chronic viral infection promotes efficient germinal center B cell responses

Fallet, Bénédict
Hao, Yi
Florova, Marianna
Cornille, Karen
de Los Aires, Alba Verge
Girelli Zubani, Giulia
Ertuna, Yusuf I
Greiff, Victor
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Published in Cell Reports. 2020, vol. 30, no. 4, p. 1013-1026.e7
Abstract Persistent viral infections subvert key elements of adaptive immunity. To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate-reporter mice and perform adoptive B cell transfer experiments. Chronic infection yields GC B cell responses of higher cellularity than acute infections do, higher memory B cell and antibody secreting cell output for longer periods of time, a better representation of the late B cell repertoire in serum immunoglobulin, and higher titers of protective neutralizing antibodies. GC B cells of chronically infected mice are similarly hypermutated as those emerging from acute infection. They efficiently adapt to viral escape variants and even in hypermutation-impaired AID mutant mice, chronic infection selects for GC B cells with hypermutated B cell receptors (BCRs) and neutralizing antibody formation. These findings demonstrate that, unlike for CD8+ T cells, chronic viral infection drives a functional, productive, and protective GC B cell response.
Keywords AIDLCMVAffinity maturationAntibody-secreting cellChronic viral infectionGerminal center B cellsLymphocytic choriomeningitis virusMemory B cellNeutralizing antibody
PMID: 31995746
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Article (Published version) (4.4 MB) - public document Free access
Research groups La Sclérose en plaques (908)
Métastases du foie (657)
FNS: 310030_173132; 310030_173010; 323630_151472
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FALLET, Bénédict et al. Chronic viral infection promotes efficient germinal center B cell responses. In: Cell Reports, 2020, vol. 30, n° 4, p. 1013-1026.e7. doi: 10.1016/j.celrep.2019.12.023 https://archive-ouverte.unige.ch/unige:131894

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Deposited on : 2020-03-09

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