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Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children

Borzani, Irene Maria Olivia
Anooshiravani, Mehrak
Published in Pediatric Radiology. 2008, vol. 38, no. 11, p. 1201-1209
Abstract BACKGROUND: Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation (BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships to graft-versus-host disease (GVHD). The role of high-resolution CT (HRCT) is not yet well established. OBJECTIVE: To illustrate different patterns of LONIPCs on HRCT in allogeneic versus autologous BMT in order to investigate the correlation with chronic GVHD (cGVHD). MATERIALS AND METHODS: A total of 67 HRCT scans were performed in 24 patients with noninfectious pulmonary disease at least 3 months after BMT (16 allogeneic, 8 autologous). Abnormality patterns and extension on HRCT images were correlated with the clinical outcome and with the severity of cGVHD. RESULTS: Of 24 patients, 9 showed LONIPCs (1 autologous, 8 allogeneic). There was a significant association between abnormalities on HRCT and severe cGVHD (P = 0.038), with no specific pattern. Prognosis seemed to be related to the severity of cGVHD and not to the extent of abnormalities on HRCT. CONCLUSION: The significant association between abnormalities on HRCT and severe GVHD suggests that LONIPCs can be a pulmonary manifestation of the disease. HRCT is a useful tool when combined with clinical data.
Keywords AdolescentBone Marrow TransplantationChildChild, PreschoolFemaleGraft vs Host Disease/radiographyHumansInfantLongitudinal StudiesLung Diseases/radiographyMalePostoperative Complications/radiographyTomography, X-Ray Computed/methodsTransplantation, AutologousTransplantation, Homologous
Stable URL https://archive-ouverte.unige.ch/unige:1315
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PMID: 18769910
Research groups Radiologie neuro-diagnostique et neuro-interventionnelle en pédiatrie (842)
Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)

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Deposited on : 2009-04-02

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