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Scientific article
Open access
English

Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children

Published inPediatric radiology, vol. 38, no. 11, p. 1201-1209
Collection
  • Open Access - Licence nationale Springer
Publication date2008
Abstract

BACKGROUND: Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation (BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships to graft-versus-host disease (GVHD). The role of high-resolution CT (HRCT) is not yet well established. OBJECTIVE: To illustrate different patterns of LONIPCs on HRCT in allogeneic versus autologous BMT in order to investigate the correlation with chronic GVHD (cGVHD). MATERIALS AND METHODS: A total of 67 HRCT scans were performed in 24 patients with noninfectious pulmonary disease at least 3 months after BMT (16 allogeneic, 8 autologous). Abnormality patterns and extension on HRCT images were correlated with the clinical outcome and with the severity of cGVHD. RESULTS: Of 24 patients, 9 showed LONIPCs (1 autologous, 8 allogeneic). There was a significant association between abnormalities on HRCT and severe cGVHD (P = 0.038), with no specific pattern. Prognosis seemed to be related to the severity of cGVHD and not to the extent of abnormalities on HRCT. CONCLUSION: The significant association between abnormalities on HRCT and severe GVHD suggests that LONIPCs can be a pulmonary manifestation of the disease. HRCT is a useful tool when combined with clinical data.

Keywords
  • Adolescent
  • Bone Marrow Transplantation
  • Child
  • Child, Preschool
  • Female
  • Graft vs Host Disease/radiography
  • Humans
  • Infant
  • Longitudinal Studies
  • Lung Diseases/radiography
  • Male
  • Postoperative Complications/radiography
  • Tomography, X-Ray Computed/methods
  • Transplantation, Autologous
  • Transplantation, Homologous
Citation (ISO format)
MERLINI, Laura et al. Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children. In: Pediatric radiology, 2008, vol. 38, n° 11, p. 1201–1209. doi: 10.1007/s00247-008-0984-9
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Article (Published version)
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Identifiers
ISSN of the journal0301-0449
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