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Scientific article
English

Increased association of telomerase with short telomeres in yeast

Contributors

Bianchi, Alessandro; Shore, David M.

Published in

Genes & development, vol. 21, no. 14, p. 1726-1730

Publication date

2007

Abstract

Telomere function is mediated by the assembly of a protein complex on an array of telomeric DNA (TG) repeats synthesized by the telomerase enzyme. Telomerase action at chromosome ends is finely tuned by the telomeric complex so that a constant average number of repeats is maintained. This is achieved through a negative feedback process that is sensitive to TG tract length, but whose underlying mechanism is unknown. We show that short telomeres, which are preferential substrates for telomerase, display increased association with the enzyme in the S phase of the cell cycle, when telomerase acts. In addition, we provide support for a molecular mechanism by which this key step of telomerase recruitment is regulated by TG tract length.

UNIGE affiliation entities

Citation (ISO format)

BIANCHI, Alessandro, SHORE, David M. Increased association of telomerase with short telomeres in yeast. In: Genes & development, 2007, vol. 21, n° 14, p. 1726–1730. doi: 10.1101/gad.438907

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0890-9369
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Technical informations

Creation

11/01/2011 11:09:00

First validation

11/01/2011 11:09:00

Update

14/03/2023 16:11:26

Status update

14/03/2023 16:11:26

Last indexation

29/10/2024 17:41:27
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