UNIGE document Scientific Article
previous document  unige:13145  next document
add to browser collection

Increased association of telomerase with short telomeres in yeast

Bianchi, Alessandro
Published in Genes and Development. 2007, vol. 21, no. 14, p. 1726 - 1730
Abstract Telomere function is mediated by the assembly of a protein complex on an array of telomeric DNA (TG) repeats synthesized by the telomerase enzyme. Telomerase action at chromosome ends is finely tuned by the telomeric complex so that a constant average number of repeats is maintained. This is achieved through a negative feedback process that is sensitive to TG tract length, but whose underlying mechanism is unknown. We show that short telomeres, which are preferential substrates for telomerase, display increased association with the enzyme in the S phase of the cell cycle, when telomerase acts. In addition, we provide support for a molecular mechanism by which this key step of telomerase recruitment is regulated by TG tract length.
Full text
Article (Published version) (413 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
BIANCHI, Alessandro, SHORE, David M. Increased association of telomerase with short telomeres in yeast. In: Genes and Development, 2007, vol. 21, n° 14, p. 1726 - 1730. doi: 10.1101/gad.438907 https://archive-ouverte.unige.ch/unige:13145

344 hits

1 download


Deposited on : 2011-01-11

Export document
Format :
Citation style :