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Circadian Rhythms: Mechanisms and Therapeutic Implications

Levi, Francis
Published in Annual Review of Pharmacology and Toxicology. 2007, vol. 47, no. 1, p. 593 - 628
Abstract The mammalian circadian system is organized in a hierarchical manner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscillators in most peripheral body cells. Fasting-feeding cycles accompanying rest-activity rhythms are the major timing cues in the synchronization of many, if not most, peripheral clocks, suggesting that the temporal coordination of metabolism and proliferation is a major task of the mammalian timing system. The inactivation of noxious food components by hepatic, intestinal, and renal detoxification systems is among the metabolic processes regulated in a circadian manner, with the understanding of the involved clock output pathways emerging. The rhythmic control of xenobiotic detoxification provides the molecular basis for the dosing time-dependence of drug toxicities and efficacy. This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.
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LEVI, Francis, SCHIBLER, Ulrich. Circadian Rhythms: Mechanisms and Therapeutic Implications. In: Annual Review of Pharmacology and Toxicology, 2007, vol. 47, n° 1, p. 593 - 628. doi: 10.1146/annurev.pharmtox.47.120505.105208 https://archive-ouverte.unige.ch/unige:13142

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Deposited on : 2011-01-10

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