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Scientific article
English

Circadian Rhythms: Mechanisms and Therapeutic Implications

Contributors

Levi, Francis; Schibler, Ulrich

Published in

Annual review of pharmacology and toxicology, vol. 47, no. 1, p. 593-628

Publication date

2007

Abstract

The mammalian circadian system is organized in a hierarchical manner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscillators in most peripheral body cells. Fasting-feeding cycles accompanying rest-activity rhythms are the major timing cues in the synchronization of many, if not most, peripheral clocks, suggesting that the temporal coordination of metabolism and proliferation is a major task of the mammalian timing system. The inactivation of noxious food components by hepatic, intestinal, and renal detoxification systems is among the metabolic processes regulated in a circadian manner, with the understanding of the involved clock output pathways emerging. The rhythmic control of xenobiotic detoxification provides the molecular basis for the dosing time-dependence of drug toxicities and efficacy. This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases.

UNIGE affiliation entities

Citation (ISO format)

LEVI, Francis, SCHIBLER, Ulrich. Circadian Rhythms: Mechanisms and Therapeutic Implications. In: Annual review of pharmacology and toxicology, 2007, vol. 47, n° 1, p. 593–628. doi: 10.1146/annurev.pharmtox.47.120505.105208

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0362-1642
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Technical informations

Creation

10/01/2011 17:26:00

First validation

10/01/2011 17:26:00

Update

14/03/2023 16:11:25

Status update

14/03/2023 16:11:25

Last indexation

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