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Title

PTEN at the crossroad of metabolic diseases and cancer in the liver

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Published in Annals of Hepatology. 2008, vol. 7, no. 3, p. 192-199
Abstract The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV and HCV infection, or following alcohol-related injury. Finally, PTEN mutations/deletions or low PTEN expression are associated with diverse liver malignancies thus suggesting a critical role for PTEN in hepatic cancers. This review will focus on our current knowledge of the regulation of PTEN expression/activity and the role of this phosphatase in liver diseases.
Keywords 1-Phosphatidylinositol 3-Kinase/metabolismEnzyme Inhibitors/pharmacologyFatty Liver/enzymologyGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHepatitis B/enzymologyHepatitis C/enzymologyHumansInsulin/metabolismInsulin ResistanceLiver/drug effects/enzymologyLiver Diseases/drug therapy/enzymology/geneticsLiver Diseases, Alcoholic/enzymologyLiver Neoplasms/drug therapy/enzymology/geneticsMutationPTEN Phosphohydrolase/antagonists & inhibitors/genetics/metabolismProto-Oncogene Proteins c-akt/metabolismSignal Transduction/drug effects/genetics
Stable URL https://archive-ouverte.unige.ch/unige:1314
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PMID: 18772845
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Research group Obésité et syndrome métabolique (803)

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Deposited on : 2009-04-02

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