Scientific article

PTEN at the crossroad of metabolic diseases and cancer in the liver

Published inAnnals of hepatology, vol. 7, no. 3, p. 192-199
Publication date2008

The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV and HCV infection, or following alcohol-related injury. Finally, PTEN mutations/deletions or low PTEN expression are associated with diverse liver malignancies thus suggesting a critical role for PTEN in hepatic cancers. This review will focus on our current knowledge of the regulation of PTEN expression/activity and the role of this phosphatase in liver diseases.

  • 1-Phosphatidylinositol 3-Kinase/metabolism
  • Enzyme Inhibitors/pharmacology
  • Fatty Liver/enzymology
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Hepatitis B/enzymology
  • Hepatitis C/enzymology
  • Humans
  • Insulin/metabolism
  • Insulin Resistance
  • Liver/drug effects/enzymology
  • Liver Diseases/drug therapy/enzymology/genetics
  • Liver Diseases, Alcoholic/enzymology
  • Liver Neoplasms/drug therapy/enzymology/genetics
  • Mutation
  • PTEN Phosphohydrolase/antagonists & inhibitors/genetics/metabolism
  • Proto-Oncogene Proteins c-akt/metabolism
  • Signal Transduction/drug effects/genetics
Citation (ISO format)
VINCIGUERRA, Manlio, FOTI, Michelangelo. PTEN at the crossroad of metabolic diseases and cancer in the liver. In: Annals of hepatology, 2008, vol. 7, n° 3, p. 192–199.
Main files (1)
Article (Accepted version)
ISSN of the journal1665-2681

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