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unige:1314 
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PTEN at the crossroad of metabolic diseases and cancer in the liver |
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| Authors | ||
| Published in | Annals of Hepatology. 2008, vol. 7, no. 3, p. 192-199 | |
| Abstract | The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV and HCV infection, or following alcohol-related injury. Finally, PTEN mutations/deletions or low PTEN expression are associated with diverse liver malignancies thus suggesting a critical role for PTEN in hepatic cancers. This review will focus on our current knowledge of the regulation of PTEN expression/activity and the role of this phosphatase in liver diseases. | |
| Keywords | 1-Phosphatidylinositol 3-Kinase/metabolism — Enzyme Inhibitors/pharmacology — Fatty Liver/enzymology — Gene Expression Regulation, Enzymologic — Gene Expression Regulation, Neoplastic — Hepatitis B/enzymology — Hepatitis C/enzymology — Humans — Insulin/metabolism — Insulin Resistance — Liver/drug effects/enzymology — Liver Diseases/drug therapy/enzymology/genetics — Liver Diseases, Alcoholic/enzymology — Liver Neoplasms/drug therapy/enzymology/genetics — Mutation — PTEN Phosphohydrolase/antagonists & inhibitors/genetics/metabolism — Proto-Oncogene Proteins c-akt/metabolism — Signal Transduction/drug effects/genetics | |
| Identifiers | PMID: 18772845 | |
| Full text |
Article (Author postprint) (317 Kb) - Limited access to UNIGE Other version: http://www.medigraphic.com/espanol/e-htms/e-hepato/em-ah.htm |
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| Structures | ||
| Research group | Obésité et syndrome métabolique (803) | |
| Citation (ISO format) | VINCIGUERRA, Manlio, FOTI, Michelangelo. PTEN at the crossroad of metabolic diseases and cancer in the liver. In: Annals of Hepatology, 2008, vol. 7, n° 3, p. 192-199. https://archive-ouverte.unige.ch/unige:1314 |
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