Doctoral thesis
English

Control of proliferation by the Dpp gradient in the wing imaginal disc of Drosophila melanogaster

ContributorsWartlick, Ortrud
Defense date2010-12-13
Abstract

Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded concentration profiles that control patterning and growth of developing organs. In the imaginal discs, proliferative growth is homogeneous in space, posing the question of how morphogen concentration gradients could control position-independent growth. To understand the mechanism of proliferation control by the Dpp gradient, we quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development. On average, cells divide when Dpp signaling levels have increased by 50%. Our observations are consistent with a growth control mechanism based on temporal changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism generates position-independent growth rates.

Citation (ISO format)
WARTLICK, Ortrud. Control of proliferation by the Dpp gradient in the wing imaginal disc of Drosophila melanogaster. Doctoral Thesis, 2010. doi: 10.13097/archive-ouverte/unige:13137
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Creation20/12/2010 14:14:00
First validation20/12/2010 14:14:00
Update time14/03/2023 16:11:24
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