UNIGE document Scientific Article
previous document  unige:131059  next document
add to browser collection
Title

Postoperative memory prognosis in temporal lobe epilepsy surgery: The contribution of postictal memory

Authors
Kavan, Nicole
Published in Epilepsia. 2019, vol. 60, no. 8, p. 1639-1649
Abstract OBJECTIVE: The prediction of verbal memory decline after temporal lobe epilepsy (TLE) surgery remains difficult at an individual level. We evaluated the prognostic value of postictal memory testing in predicting the postoperative verbal memory function. METHODS: Sixty-three consecutive patients were included in the analysis who underwent TLE surgery at our center with preoperative interictal/postictal and postoperative memory testing. Verbal memory was evaluated using the Rey Auditory Verbal Learning Test (RAVLT). We used reliable change indices with 90% confidence interval (90% RCIs) to evaluate a significant postoperative memory decline. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), area under the curve (AUC), and accuracy (ACC) were calculated. The analysis was performed for all TLE patients and for the subgroup with hippocampal sclerosis (HS). RESULTS: Left-TLE patients (n = 31) had lower verbal memory scores on RAVLT than right-TLE at 3 months (57% vs 78%) and 12 months (53% vs 78%) after surgery. The 90% RCI was estimated to be a loss of 4 out of 15 items. The predictive value was Sn = 42%, Sp = 84%, PPV = 39%, NPV = 86%, AUC = 0.630, and ACC = 76% to predict a verbal memory decline in the whole group (n = 63). In HS patients (n = 41), the postictal verbal memory test had Sn = 50%, Sp = 88%, PPV = 50%, NPV = 88%, AUC = 0.689, and ACC = 81% to predict a significant postoperative decline. SIGNIFICANCE: Postictal memory is a noninvasive bedside memory test that can help predict the postoperative verbal memory decline in patients with HS with an overall accuracy of 81%.
Keywords Epilepsy surgeryHippocampal sclerosisPharmacoresistant epilepsyPostictal memoryPostoperative memoryVerbal memory
Identifiers
PMID: 31329286
Full text
Article (Published version) (769 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Supplemental data (64 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://onlinelibrary.wiley.com/doi/full/10.1111/epi.16281
Structures
Research groups Epilepsie et réseaux cérébraux (1002)
Neuropsychologie et neurologie comportementale (951)
Groupe Schaller Karl Lothard (neurochirurgie) (851)
Epilepsie et Chirurgie (149)
Projects
FNS: 169198, 320030‐163398 & Sinergia 170873 and 180365
Autre: FLAG‐ERA, JTC2017, SCALES
Citation
(ISO format)
SVEIKATA, Lukas et al. Postoperative memory prognosis in temporal lobe epilepsy surgery: The contribution of postictal memory. In: Epilepsia, 2019, vol. 60, n° 8, p. 1639-1649. doi: 10.1111/epi.16281 https://archive-ouverte.unige.ch/unige:131059

214 hits

2 downloads

Update

Deposited on : 2020-02-20

Export document
Format :
Citation style :