We generalize the stochastic path integral formalism by considering Hamiltonian dynamics in the presence of general Markovian noise. Kramers' solution of the activation rate for escape over a barrier is generalized for non-Gaussian driving noise in both the overdamped and underdamped limit. We apply our general results to a Josephson junction detector measuring the electron counting statistics of a mesoscopic conductor. The activation rate dependence on the third current cumulant includes an additional term originating from the backaction of the measurement circuit.