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Subcortical electrophysiological activity is detectable with high-density EEG source imaging

Hoevels, Mauritius
Sesia, Thibaut
Visser-Vandewalle, Veerle
Published in Nature communications. 2019, vol. 10, no. 1, 753
Abstract Subcortical neuronal activity is highly relevant for mediating communication in large-scale brain networks. While electroencephalographic (EEG) recordings provide appropriate temporal resolution and coverage to study whole brain dynamics, the feasibility to detect subcortical signals is a matter of debate. Here, we investigate if scalp EEG can detect and correctly localize signals recorded with intracranial electrodes placed in the centromedial thalamus, and in the nucleus accumbens. Externalization of deep brain stimulation (DBS) electrodes, placed in these regions, provides the unique opportunity to record subcortical activity simultaneously with high-density (256 channel) scalp EEG. In three patients during rest with eyes closed, we found significant correlation between alpha envelopes derived from intracranial and EEG source reconstructed signals. Highest correlation was found for source signals in close proximity to the actual recording sites, given by the DBS electrode locations. Therefore, we present direct evidence that scalp EEG indeed can sense subcortical signals.
Keywords Brain/diagnostic imaging/physiology/physiopathologyBrain MappingDeep Brain Stimulation/methodsElectrodesElectroencephalography/instrumentation/methodsElectrophysiological PhenomenaHumansIntralaminar Thalamic Nuclei/diagnostic imaging/physiology/physiopathologyMagnetic Resonance ImagingNucleus Accumbens/diagnostic imaging/physiology/physiopathologyObsessive-Compulsive Disorder/diagnostic imaging/physiopathology/therapyScalp/diagnostic imaging/physiology/physiopathologyTomographyX-Ray ComputedTourette Syndrome/diagnostic imaging/physiopathology/therapy
PMID: 30765707
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Research groups NCCR Synapsy
Organisation et plasticité des réseaux neuronaux cérébraux (148)
Swiss National Science Foundation: 320030_159705
Swiss National Science Foundation: NCCR Synapsy 51NF40-158776
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SEEBER, Martin et al. Subcortical electrophysiological activity is detectable with high-density EEG source imaging. In: Nature Communications, 2019, vol. 10, n° 1, p. 753. doi: 10.1038/s41467-019-08725-w https://archive-ouverte.unige.ch/unige:129925

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Deposited on : 2020-02-03

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