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Scientific article
English

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

Published inNature Cell Biology, vol. 1, no. 2, p. 88-93
Publication date1999
Abstract

Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, the centrosome must be duplicated once, and only once, in each cell cycle. How centrosome duplication is regulated and coordinated with other cell-cycle functions remains poorly understood. Here, we have established a centrosome duplication assay using mammalian somatic cells. We show that centrosome duplication requires the activation of E2F transcription factors and Cdk2–cyclin A activity.

Citation (ISO format)
MERALDI, Patrick et al. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A. In: Nature Cell Biology, 1999, vol. 1, n° 2, p. 88–93. doi: 10.1038/10054
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ISSN of the journal1465-7392
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